HCSGD entry for BCL2A1
1. General information
| Official gene symbol | BCL2A1 |
|---|---|
| Entrez ID | 597 |
| Gene full name | BCL2-related protein A1 |
| Other gene symbols | ACC-1 ACC-2 BCL2L5 BFL1 GRS HBPA1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005741 | Mitochondrial outer membrane | IBA | cellular_component |
| GO:0008630 | Intrinsic apoptotic signaling pathway in response to DNA damage | IBA | biological_process |
| GO:0042803 | Protein homodimerization activity | IBA | molecular_function |
| GO:0043066 | Negative regulation of apoptotic process | IBA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IBA | molecular_function |
| GO:0051400 | BH domain binding | IEA | molecular_function |
| GO:0097192 | Extrinsic apoptotic signaling pathway in absence of ligand | IBA | biological_process |
| GO:2001243 | Negative regulation of intrinsic apoptotic signaling pathway | IBA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0000231412 | 0.8137682915 | 0.0149063830 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.0917074234 |
| GSE13712_SHEAR | Up | 0.8423559076 |
| GSE13712_STATIC | Up | 2.0173325885 |
| GSE19018 | Down | -0.3545445605 |
| GSE19899_A1 | Up | 5.8953512959 |
| GSE19899_A2 | Up | 8.4148526818 |
| PubMed_21979375_A1 | Up | 8.3367258585 |
| PubMed_21979375_A2 | Up | 6.7823932724 |
| GSE35957 | Down | -0.3727910650 |
| GSE36640 | Down | -1.3825035508 |
| GSE54402 | Up | 3.3027230784 |
| GSE9593 | Up | 0.1922219445 |
| GSE43922 | Up | 2.4163871481 |
| GSE24585 | Up | 0.5457723775 |
| GSE37065 | Up | 0.2430005113 |
| GSE28863_A1 | Up | 0.0283852895 |
| GSE28863_A2 | Down | -0.2873843344 |
| GSE28863_A3 | Up | 0.0844900787 |
| GSE28863_A4 | Up | 0.0608431036 |
| GSE48662 | Down | -0.0304026644 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017218 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-146a-5p | MIMAT0000449 | MIRT021264 | Microarray | Functional MTI (Weak) | 18057241 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22919441 | Gene expression analysis showed that GTT treatment down regulated BAX mRNA, up-regulated BCL2A1 mRNA and decreased the ratio of Bax/Bcl-2 protein expression (P < 0 |
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