HCSGD entry for RECQL
1. General information
| Official gene symbol | RECQL |
|---|---|
| Entrez ID | 5965 |
| Gene full name | RecQ protein-like (DNA helicase Q1-like) |
| Other gene symbols | RECQL1 RecQ1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000733 | DNA strand renaturation | IDA | biological_process |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003678 | DNA helicase activity | IDA | molecular_function |
| GO:0004003 | ATP-dependent DNA helicase activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006200 | ATP catabolic process | TAS | biological_process |
| GO:0006260 | DNA replication | IEA | biological_process |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006310 | DNA recombination | IEA | biological_process |
| GO:0008026 | ATP-dependent helicase activity | IEA | molecular_function |
| GO:0015630 | Microtubule cytoskeleton | IDA | cellular_component |
| GO:0032508 | DNA duplex unwinding | IDA TAS | biological_process |
| GO:0036310 | Annealing helicase activity | IDA | molecular_function |
| GO:0043140 | ATP-dependent 3'-5' DNA helicase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0743802933 | 0.5941499601 | 0.5787063849 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1095255892 |
| GSE13712_SHEAR | Up | 0.2431123227 |
| GSE13712_STATIC | Up | 0.2244800892 |
| GSE19018 | Down | -0.2188692993 |
| GSE19899_A1 | Up | 1.0122264801 |
| GSE19899_A2 | Down | -0.2232646035 |
| PubMed_21979375_A1 | Up | 0.3733395224 |
| PubMed_21979375_A2 | Down | -0.2048352188 |
| GSE35957 | Down | -0.3542203953 |
| GSE36640 | Down | -0.2525966302 |
| GSE54402 | Up | 0.3635455276 |
| GSE9593 | Down | -0.1963508656 |
| GSE43922 | Up | 0.4758259221 |
| GSE24585 | Up | 0.3405422680 |
| GSE37065 | Up | 0.1960206014 |
| GSE28863_A1 | Up | 0.1610533950 |
| GSE28863_A2 | Up | 0.1879680449 |
| GSE28863_A3 | Down | -0.5020980994 |
| GSE28863_A4 | Up | 0.0765736060 |
| GSE48662 | Down | -0.2276130294 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024543 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026858 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030018 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049712 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24832598 | We first systematically investigated whether depletion of RECQL4 and the other four human RecQ helicases, BLM, WRN, RECQL1 and RECQL5, impacts the proliferative potential of human primary fibroblasts |
| 24832598 | These features were less frequent in RECQL1- and RECQL5-depleted cells |
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