HCSGD entry for RBP2
1. General information
| Official gene symbol | RBP2 |
|---|---|
| Entrez ID | 5948 |
| Gene full name | retinol binding protein 2, cellular |
| Other gene symbols | CRABP-II CRBP2 CRBPII RBPC2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001523 | Retinoid metabolic process | TAS | biological_process |
| GO:0005215 | Transporter activity | IEA | molecular_function |
| GO:0005501 | Retinoid binding | TAS | molecular_function |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA TAS | cellular_component |
| GO:0006776 | Vitamin A metabolic process | TAS | biological_process |
| GO:0007603 | Phototransduction, visible light | TAS | biological_process |
| GO:0008544 | Epidermis development | TAS | biological_process |
| GO:0016918 | Retinal binding | IEA | molecular_function |
| GO:0019841 | Retinol binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5148030736 | 0.8979795107 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0431885616 |
| GSE13712_SHEAR | Up | 0.0201476623 |
| GSE13712_STATIC | Up | 0.0250269921 |
| GSE19018 | Up | 0.3472344238 |
| GSE19899_A1 | Up | 0.0893712431 |
| GSE19899_A2 | Down | -0.2244662349 |
| PubMed_21979375_A1 | Up | 0.1451869974 |
| PubMed_21979375_A2 | Down | -0.0251222320 |
| GSE35957 | Up | 0.0872032448 |
| GSE36640 | Down | -0.0154900711 |
| GSE54402 | Down | -0.0259824354 |
| GSE9593 | Up | 0.1670731740 |
| GSE43922 | Up | 0.0902444140 |
| GSE24585 | Down | -0.0107204633 |
| GSE37065 | Down | -0.0113784684 |
| GSE28863_A1 | Up | 0.1010002583 |
| GSE28863_A2 | Up | 0.0176910532 |
| GSE28863_A3 | Up | 0.1659270067 |
| GSE28863_A4 | Up | 0.0368024404 |
| GSE48662 | Up | 0.0235611182 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23922798 | RESULTS: The expression of RBP2 was stronger in cancerous than non-cancerous tissues, but that of its binding microRNA, Homo sapiens miR-212 (hsa-miR-212), showed an opposite pattern |
| 23922798 | SiRNA knockdown of RBP2 significantly upregulated cyclin-dependent kinase inhibitors (CDKIs), with suppression of HCC cell proliferation and induction of senescence |
| 23922798 | Inhibition of hsa-miR-212 expression upregulated RBP2 expression |
| 19850045 | The histone demethylase RBP2 Is overexpressed in gastric cancer and its inhibition triggers senescence of cancer cells |
| 19850045 | It is unclear whether RBP2, a newly identified histone demethylase, is involved in cancer development/progression |
| 19850045 | We determined RBP2 expression in gastric cancer and its biologic function in cancer cells |
| 19850045 | METHODS: Cancerous and matched normal gastric specimens from 42 patients with gastric cancer were analyzed for RBP2 expression using quantitative real-time polymerase chain reaction and immunohistochemistry |
| 19850045 | Chromatin immunoprecipitation was used to detect RBP2 and methylated histone H3-K4 on promoters |
| 19850045 | RESULTS: RBP2 messenger RNA and protein expression were increased in 71 |
| 19850045 | The promoter activity of all 3 CDKIs genes was enhanced by RBP2 inhibition |
| 19850045 | RBP2 occupied these promoters in control cells, and the loss of RBP2 occupancy was accompanied by enhanced H3-K4 trimethylation following RBP2 depletion |
| 19850045 | RBP2 occupied these promoters in control cells, and the loss of RBP2 occupancy was accompanied by enhanced H3-K4 trimethylation following RBP2 depletion |
| 19850045 | RBP2 occupied these promoters in control cells, and the loss of RBP2 occupancy was accompanied by enhanced H3-K4 trimethylation following RBP2 depletion |
| 19850045 | CONCLUSIONS: RBP2 is overexpressed in gastric cancer, and its inhibition triggers senescence of malignant cells at least partially by derepressing its target genes CDKIs |
| 19850045 | Histone demethylase inhibition by targeting RBP2 may be an anticancer strategy |
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