HCSGD entry for BCKDHB
1. General information
| Official gene symbol | BCKDHB |
|---|---|
| Entrez ID | 594 |
| Gene full name | branched chain keto acid dehydrogenase E1, beta polypeptide |
| Other gene symbols | E1B dJ279A18.1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003826 | Alpha-ketoacid dehydrogenase activity | IEA | molecular_function |
| GO:0003863 | 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005739 | Mitochondrion | IMP | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0005947 | Mitochondrial alpha-ketoglutarate dehydrogenase complex | IMP | cellular_component |
| GO:0007584 | Response to nutrient | IEA | biological_process |
| GO:0009083 | Branched-chain amino acid catabolic process | IMP TAS | biological_process |
| GO:0016831 | Carboxy-lyase activity | TAS | molecular_function |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0051384 | Response to glucocorticoid | IEA | biological_process |
| GO:0051591 | Response to cAMP | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9960043197 | 0.0015140686 | 0.9999902473 | 0.0756859848 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3177233993 |
| GSE13712_SHEAR | Down | -0.4733230036 |
| GSE13712_STATIC | Down | -0.1133988255 |
| GSE19018 | Up | 0.1658367126 |
| GSE19899_A1 | Down | -0.6680067616 |
| GSE19899_A2 | Down | -1.4513241729 |
| PubMed_21979375_A1 | Down | -1.7573801908 |
| PubMed_21979375_A2 | Down | -1.0682623838 |
| GSE35957 | Down | -0.2690075694 |
| GSE36640 | Down | -0.3271151553 |
| GSE54402 | Down | -0.7087063392 |
| GSE9593 | Down | -0.2150706373 |
| GSE43922 | Down | -1.3874279475 |
| GSE24585 | Up | 0.4750517225 |
| GSE37065 | Down | -0.4559340183 |
| GSE28863_A1 | Down | -0.0184050879 |
| GSE28863_A2 | Down | -0.0491829947 |
| GSE28863_A3 | Down | -0.8514646207 |
| GSE28863_A4 | Down | -0.2564792246 |
| GSE48662 | Down | -0.5188968594 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT001381 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 1652450 | Similarly, combinations of adenovirus E1A + E1B or human papillomavirus E6 + E7 genes are able to replace T-antigen functions and permit cell proliferation, whereas the individual genes do not |
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