HCSGD entry for HRH4
1. General information
| Official gene symbol | HRH4 |
|---|---|
| Entrez ID | 59340 |
| Gene full name | histamine receptor H4 |
| Other gene symbols | AXOR35 BG26 GPCR105 GPRv53 H4 H4R HH4R |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004969 | Histamine receptor activity | NAS | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0007204 | Positive regulation of cytosolic calcium ion concentration | IEA | biological_process |
| GO:0008150 | Biological_process | ND | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0043408 | Regulation of MAPK cascade | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4395671783 | 0.8942515482 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0533542801 |
| GSE13712_SHEAR | Up | 0.1398031798 |
| GSE13712_STATIC | Down | -0.0507355565 |
| GSE19018 | Up | 0.0245865228 |
| GSE19899_A1 | Up | 0.0697419009 |
| GSE19899_A2 | Up | 0.1190621717 |
| PubMed_21979375_A1 | Down | -0.1414303563 |
| PubMed_21979375_A2 | Up | 0.0083459243 |
| GSE35957 | Up | 0.1891383244 |
| GSE36640 | Up | 0.1491332508 |
| GSE54402 | Up | 0.0353567323 |
| GSE9593 | Up | 0.0712221029 |
| GSE43922 | Up | 0.2465986318 |
| GSE24585 | Down | -0.3001169337 |
| GSE37065 | Up | 0.0412381777 |
| GSE28863_A1 | Down | -0.0132163787 |
| GSE28863_A2 | Down | -0.0369118407 |
| GSE28863_A3 | Up | 0.1226661023 |
| GSE28863_A4 | Up | 0.0155267495 |
| GSE48662 | Up | 0.1380503124 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Olanzapine | DB00334 | APRD00138 |
| Clozapine | DB00363 | APRD00470 |
| Loxapine | DB00408 | APRD00574 |
| Amoxapine | DB00543 | APRD00142 |
| Histamine Phosphate | DB00667 | APRD01015 |
| Doxepin | DB01142 | APRD00398 |
| REV131 | DB05032 | - |
| Mianserin | DB06148 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017500 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-148b-3p | MIMAT0000759 | MIRT019358 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21691231 | The aim of this study was to investigate the presence of histamine H4 receptor (H4R) in human melanoma cells and its associated biological processes |
| 21691231 | To better understand the importance of histamine in tumor development, we explored the expression of H4R in human melanoma tissue biopsies |
| 21691231 | The expression of H4R in WM35 and M1/15 cells was analyzed by reverse-transcription-PCR, western blot, and immunocytochemistry |
| 21691231 | The expression levels of H4R were determined by immunohistochemistry in 19 samples of human malignant lesions |
| 21691231 | Results indicate that melanoma cells express H4R at the messenger RNA and protein levels |
| 21691231 | By using histamine agonists, antagonists, and H4R small-interfering RNA we showed that the inhibitory effect of histamine on proliferation was in part mediated through the stimulation of the H4R |
| 21691231 | Furthermore, H4R was expressed in 42% of human melanoma biopsies |
| 21691231 | To our knowledge, this is the first report that describes the presence of the H4R in melanoma cells and tissue, suggesting a potential therapeutic application of H4R ligands |
| 21622113 | Role of histamine H4 receptor in breast cancer cell proliferation |
| 21622113 | In order to better understand the role of histamine H4 (H4R) receptor in breast cancer, we studied the receptor expression pattern, associated signal transduction pathway and biological responses, in breast cancer cell lines with different malignant characteristics |
| 21622113 | A different pattern of protein expression was observed in MDA-MB-231 compared to MCF-7 cells determined by western blot, exhibiting the presence of a diverse range of molecular weight species of the H4R |
| 21622113 | H4R agonist reduced cyclic adenosine monophosphate (cAMP) formation induced by forskolin only in MCF-7 cells |
| 21622113 | In MDA-MB-231 cells, H4R agonists significantly decreased cell proliferation, augmented the Annexin-V and TdT-mediated UTP-biotin Nick End labelling (TUNEL) positive cells and produced a 2 |
| 21622113 | In MCF-7 cells, H4R agonists inhibited proliferation by 50%, increasing the exponential doubling time |
| 21622113 | We conclude that H4R is functionally expressed in human breast cancer cell lines, exhibiting a key role in histamine-mediated biological processes such as cell proliferation, senescence and apoptosis |
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