HCSGD entry for RBL2
1. General information
| Official gene symbol | RBL2 |
|---|---|
| Entrez ID | 5934 |
| Gene full name | retinoblastoma-like 2 (p130) |
| Other gene symbols | P130 Rb2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005667 | Transcription factor complex | IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0016568 | Chromatin modification | IEA | biological_process |
| GO:0043550 | Regulation of lipid kinase activity | IDA | biological_process |
| GO:0051726 | Regulation of cell cycle | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9253210934 | 0.0727824893 | 0.9999902473 | 0.5086850505 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2717572676 |
| GSE13712_SHEAR | Down | -0.4146365900 |
| GSE13712_STATIC | Down | -0.3183340401 |
| GSE19018 | Up | 0.2302860583 |
| GSE19899_A1 | Down | -0.0635653556 |
| GSE19899_A2 | Down | -0.4601028413 |
| PubMed_21979375_A1 | Down | -0.8404549201 |
| PubMed_21979375_A2 | Down | -0.1460857148 |
| GSE35957 | Down | -0.1666440884 |
| GSE36640 | Up | 0.0000362770 |
| GSE54402 | Up | 0.0032079607 |
| GSE9593 | Up | 0.0206381694 |
| GSE43922 | Down | -0.0719478366 |
| GSE24585 | Up | 0.2272347734 |
| GSE37065 | Down | -0.0085986201 |
| GSE28863_A1 | Up | 0.3716572985 |
| GSE28863_A2 | Up | 0.2682003919 |
| GSE28863_A3 | Down | -0.6613532485 |
| GSE28863_A4 | Down | -0.1582638478 |
| GSE48662 | Down | -0.4316681163 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-192-5p | MIMAT0000222 | MIRT004139 | Microarray | Functional MTI (Weak) | 16822819 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT005852 | Luciferase reporter assay | Functional MTI | 21283765 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT005859 | Luciferase reporter assay | Functional MTI | 21283765 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT005859 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT005867 | Luciferase reporter assay | Functional MTI | 21283765 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT005867 | Luciferase reporter assay | Functional MTI | 23377830 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT005867 | Microarray | Functional MTI (Weak) | 17242205 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT019207 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25093008 | Large subpopulations of tumor cells expressed the RBL2 pocket protein and senescence associated heterochromatin 1gamma and IL8 receptor beta |
| 21465484 | The switch from pRb/p105 to Rb2/p130 in DNA damage and cellular senescence |
| 21465484 | Here, we discuss the functional relevance of the switch from pRb/p105 to Rb2/p130 that becomes apparent when cells enter senescent arrest |
| 19668264 | Senescence and p130/Rbl2: a new beginning to the end |
| 19668264 | We will first summarize the data supporting these claims and then highlight the specific role that we hypothesize that p130/Rbl2 plays in the modulation of the senescence process |
| 19648966 | Rb2/p130 is the dominating pocket protein in the p53-p21 DNA damage response pathway leading to senescence |
| 19648966 | Here, we show that in a broad range of wild-type p53-expressing human tumor cells, and in human diploid fibroblasts, Rb2/p130 is the dominating pocket protein in replicative and in accelerated senescence |
| 19648966 | Expression of cyclin A and entry into S-phase resumed after RNA interference-mediated knockdown of Rb2/p130 |
| 19648966 | Activation of different upstream pathways by overexpression of either p21 or p16 converged on Rb2/p130 accumulation and induced senescence |
| 19648966 | In contrast, p53- or p21-negative cells treated with DNA-damaging agents failed to accumulate Rb2/p130 and to enter senescence |
| 19648966 | Our data suggest that Rb2/p130 is a member of the p53-p21 DNA damage signaling cascade, and represents the essential pocket protein family member needed for the induction of any type of senescence |
| 16936745 | Regulation of cellular senescence by Rb2/p130 |
| 16936745 | Growth regulatory functions of Rb2/p130, which aim at a sustained arrest such as in quiescent or differentiated cells, qualify the protein also to act as a central regulator of growth arrest in cellular senescence |
| 16936745 | In this respect, Rb2/p130 functions are connected to signaling pathways induced by p53, which is a master regulator in cellular senescence |
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