HCSGD entry for PLEKHA1
1. General information
| Official gene symbol | PLEKHA1 |
|---|---|
| Entrez ID | 59338 |
| Gene full name | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 |
| Other gene symbols | TAPP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001553 | Luteinization | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0007283 | Spermatogenesis | IEA | biological_process |
| GO:0008209 | Androgen metabolic process | IEA | biological_process |
| GO:0008210 | Estrogen metabolic process | IEA | biological_process |
| GO:0009791 | Post-embryonic development | IEA | biological_process |
| GO:0014065 | Phosphatidylinositol 3-kinase signaling | IDA | biological_process |
| GO:0030165 | PDZ domain binding | IPI | molecular_function |
| GO:0031529 | Ruffle organization | IDA | biological_process |
| GO:0032587 | Ruffle membrane | IDA | cellular_component |
| GO:0033327 | Leydig cell differentiation | IEA | biological_process |
| GO:0035264 | Multicellular organism growth | IEA | biological_process |
| GO:0043325 | Phosphatidylinositol-3,4-bisphosphate binding | IDA | molecular_function |
| GO:0045184 | Establishment of protein localization | IDA | biological_process |
| GO:0048008 | Platelet-derived growth factor receptor signaling pathway | IEA | biological_process |
| GO:0048705 | Skeletal system morphogenesis | IEA | biological_process |
| GO:0050853 | B cell receptor signaling pathway | IDA | biological_process |
| GO:0051898 | Negative regulation of protein kinase B signaling | IMP | biological_process |
| GO:0060021 | Palate development | IEA | biological_process |
| GO:0060325 | Face morphogenesis | IEA | biological_process |
| GO:0070301 | Cellular response to hydrogen peroxide | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1185888454 | 0.4643183428 | 0.7063136878 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2905046115 |
| GSE13712_SHEAR | Up | 0.0922651688 |
| GSE13712_STATIC | Down | -0.1160885958 |
| GSE19018 | Up | 0.1761404070 |
| GSE19899_A1 | Down | -0.5375488412 |
| GSE19899_A2 | Up | 0.4004944758 |
| PubMed_21979375_A1 | Up | 0.6880863002 |
| PubMed_21979375_A2 | Down | -0.0403777829 |
| GSE35957 | Up | 0.7437392580 |
| GSE36640 | Up | 1.1747686457 |
| GSE54402 | Down | -0.5680403127 |
| GSE9593 | Up | 0.3391645662 |
| GSE43922 | Down | -0.1089506515 |
| GSE24585 | Up | 0.0463798869 |
| GSE37065 | Up | 0.0030241827 |
| GSE28863_A1 | Up | 0.0671481656 |
| GSE28863_A2 | Up | 0.0670228647 |
| GSE28863_A3 | Down | -0.0923156589 |
| GSE28863_A4 | Down | -0.0317341812 |
| GSE48662 | Up | 0.5777026810 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Citric Acid | DB04272 | EXPT00922 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-590-3p | MIMAT0004801 | MIRT016210 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017173 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022329 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028076 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028276 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029065 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030792 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-769-5p | MIMAT0003886 | MIRT039173 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
