HCSGD entry for RBL1
1. General information
| Official gene symbol | RBL1 |
|---|---|
| Entrez ID | 5933 |
| Gene full name | retinoblastoma-like 1 (p107) |
| Other gene symbols | CP107 PRB1 p107 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005667 | Transcription factor complex | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | TAS | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | TAS | biological_process |
| GO:0008134 | Transcription factor binding | IPI | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016568 | Chromatin modification | IEA | biological_process |
| GO:0043550 | Regulation of lipid kinase activity | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0051726 | Regulation of cell cycle | IEA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8425126895 | 0.0053612933 | 0.9999902473 | 0.1483513116 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1319581529 |
| GSE13712_SHEAR | Up | 0.1871292597 |
| GSE13712_STATIC | Up | 0.2888018768 |
| GSE19018 | Down | -0.2912746442 |
| GSE19899_A1 | Up | 0.0194868653 |
| GSE19899_A2 | Down | -2.0036077531 |
| PubMed_21979375_A1 | Down | -1.0189717318 |
| PubMed_21979375_A2 | Down | -1.2591556146 |
| GSE35957 | Down | -0.8209616509 |
| GSE36640 | Down | -2.3206282927 |
| GSE54402 | Down | -0.6360154623 |
| GSE9593 | Down | -0.0268133775 |
| GSE43922 | Down | -1.5725266302 |
| GSE24585 | Up | 0.1511669456 |
| GSE37065 | Down | -0.1713941244 |
| GSE28863_A1 | Down | -0.1166066270 |
| GSE28863_A2 | Up | 0.8086319072 |
| GSE28863_A3 | Down | -0.3469104143 |
| GSE28863_A4 | Up | 0.3741844276 |
| GSE48662 | Down | -0.3420151363 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-17-5p | MIMAT0000070 | MIRT005851 | Luciferase reporter assay | Functional MTI | 21283765 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT005858 | Luciferase reporter assay | Functional MTI | 21283765 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT005866 | Luciferase reporter assay | Functional MTI | 21283765 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 14 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23370776 | Of note, acute lowering of P107 did not induce relevant changes in the in vitro behavior of MSC |
| 22333593 | RB family proteins pRb, p107 and p130 have similar structures and overlapping functions, enabling cell cycle arrest and cellular senescence |
| 22333593 | In human fibroblasts acutely exposed to oncogenic ras, pRb has a specific role in suppressing DNA replication, and p107 or p130 cannot compensate for the loss of this function; however, a second p53/p21-dependent checkpoint prevents escape from growth arrest |
| 22333593 | However, senescence induction by endogenous p16 was delayed in primary normal human mammary epithelial cells with reduced pRb but not with reduced p107 or p130 |
| 22333593 | Thus, under these circumstances, despite the presence of functional p53, p107 and p130 were unable to completely compensate for pRb in mediating senescence induction |
| 20385362 | The RB protein family (RB, p107, and p130) has overlapping and compensatory functions in cell-cycle control |
| 20385355 | RB, p107, and p130 are highly related proteins, each capable of regulating cellular proliferation |
| 19737973 | Retinoblastoma family members (pRb, p107, and p130) previously implicated in gene silencing during fibroblasts senescence were found down-regulated in cells with nutlin-induced senescence-like phenotype, suggesting a mechanism for its reversibility |
| 18418057 | Distinct roles for p107 and p130 in Rb-independent cellular senescence |
| 18418057 | A small family of tumor suppressor genes encoding the retinoblastoma susceptibility protein family (Rb, p107, p130) exerts a partially redundant control of entry into S phase of DNA replication and cellular proliferation |
| 18418057 | Consistent with this hypothesis, depletion of p107 potently inhibits the irradiation-induced senescence observed in DU145 cells |
| 18418057 | The dominant effect of depleting both p107 and p130, in the absence of Rb, was a complete blockade of irradiation-induced cellular senescence |
| 18418057 | These results indicate that p107 is required for initiation of accelerated cellular senescence in the absence of Rb and introduces the concept that p130 may be required to prevent the onset of terminal growth arrest in unstimulated prostate cancer cells lacking a functional Rb allele |
| 18296649 | We observed that, in a manner reminiscent to senescent cells, permanent silencing of the E2F-dependent cdc6, dhfr, and p107 promoters in myotubes was associated with a specific increase in H3K9 trimethylation |
| 17162659 | JC virus T'135, T'136 and T'165 proteins interact with cellular p107 and p130 in vivo and influence viral transformation potential |
| 17162659 | These cell lines were used to evaluate the ability of each viral protein to bind p107 and p130 in vivo, and to influence cellular growth characteristics |
| 17162659 | Differences were observed in the abilities of individual T' proteins to bind p107 and p130 and to alter their phosphorylation status |
| 16465443 | Animals lacking Rb and/or its family members p107 and p130 have led scientists to uncover new and exciting roles for this protein family in development as well as tumor suppression |
| 16123778 | Activation of p53(Val-135) induces a switch in pocket protein expression from pRb and p107 to p130(Rb2) and stalls the cells in late G1, early S-phase at high levels of cyclin E |
| 12853964 | This difference is explained in part by functional compensation by the Rb-related gene p107 |
| 11756559 | Cdk4(R24C/R24C) mouse embryo fibroblasts (MEFs) displayed increased Cdk4 kinase activity resulting in hyperphosphorylation of all three members of the Rb family, pRb, p107, and p130 |
| 8853893 | The other two were novel E2F complexes that contained the cyclin-dependent kinase inhibitor p21 (cip1/WAF1/Sdi1/CAP20/PIC1) complexed with Rb/CDK2/cyclin E or with the Rb-related p107/CDK2/ cyclin D |
| 8853893 | Addition of purified p21 protein to the S-phase-specific cyclin A/ CDK2-p107-E2F complex from young cells dissociated cyclin A and CDK2 from p107/E2F, suggesting an additional novel function for p21 |
| 8934878 | T[K1] is a T antigen point mutant that selectively is defective in binding pRb and the pRb-related proteins p107 and p130 |
| 8934878 | It did not appear that Id-1 interacted directly with pRb or p107 |
| 8934878 | Constitutive Id-1 expression failed to rescue proliferating cells from growth inhibition by pRb, p107, or p130, and failed to interact with pRb in the yeast two hybrid system |
Entries Per Page
Displaying Page of
