HCSGD entry for SIGIRR
1. General information
| Official gene symbol | SIGIRR |
|---|---|
| Entrez ID | 59307 |
| Gene full name | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain |
| Other gene symbols | TIR8 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001960 | Negative regulation of cytokine-mediated signaling pathway | ISS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0006953 | Acute-phase response | ISS | biological_process |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0016020 | Membrane | IMP | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0031665 | Negative regulation of lipopolysaccharide-mediated signaling pathway | TAS | biological_process |
| GO:0043433 | Negative regulation of sequence-specific DNA binding transcription factor activity | IMP | biological_process |
| GO:0045079 | Negative regulation of chemokine biosynthetic process | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9665594088 | 0.0330935717 | 0.9999902473 | 0.3436117949 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1438296407 |
| GSE13712_SHEAR | Down | -0.2528522044 |
| GSE13712_STATIC | Down | -0.1831908670 |
| GSE19018 | Up | 0.0112349427 |
| GSE19899_A1 | Down | -0.5141113820 |
| GSE19899_A2 | Down | -0.6559372368 |
| PubMed_21979375_A1 | Down | -0.6398050182 |
| PubMed_21979375_A2 | Down | -0.2581277783 |
| GSE35957 | Down | -1.1687806242 |
| GSE36640 | Down | -0.2247158555 |
| GSE54402 | Down | -0.2034111995 |
| GSE9593 | Down | -0.2795956045 |
| GSE43922 | Down | -0.0378658542 |
| GSE24585 | Down | -0.0270389256 |
| GSE37065 | Up | 0.0137472657 |
| GSE28863_A1 | Down | -0.2198095542 |
| GSE28863_A2 | Down | -0.1047252422 |
| GSE28863_A3 | Up | 0.2992153397 |
| GSE28863_A4 | Up | 0.1449537997 |
| GSE48662 | Up | 0.0315758587 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017017 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045553 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
