HCSGD entry for NTN4
1. General information
| Official gene symbol | NTN4 |
|---|---|
| Entrez ID | 59277 |
| Gene full name | netrin 4 |
| Other gene symbols | PRO3091 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005604 | Basement membrane | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0016322 | Neuron remodeling | IEA | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0043237 | Laminin-1 binding | IEA | molecular_function |
| GO:0060668 | Regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0201380571 | 0.0007222598 | 0.3420940722 | 0.0506949333 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.9127466547 |
| GSE13712_SHEAR | Up | 0.6424862313 |
| GSE13712_STATIC | Down | -0.4312287159 |
| GSE19018 | Up | 0.5369851437 |
| GSE19899_A1 | Down | -4.5751434606 |
| GSE19899_A2 | Down | -1.8414033073 |
| PubMed_21979375_A1 | Down | -2.8165011413 |
| PubMed_21979375_A2 | Down | -3.0929170192 |
| GSE35957 | Up | 0.2742710521 |
| GSE36640 | Down | -0.1195850256 |
| GSE54402 | Down | -5.8088062133 |
| GSE9593 | Up | 1.6242107732 |
| GSE43922 | Down | -1.6877913271 |
| GSE24585 | Down | -0.4059533379 |
| GSE37065 | Up | 0.3019671904 |
| GSE28863_A1 | Up | 0.4239002222 |
| GSE28863_A2 | Up | 1.4669785841 |
| GSE28863_A3 | Down | -0.1135105337 |
| GSE28863_A4 | Up | 0.4453016362 |
| GSE48662 | Down | -0.4160622618 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017325 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24265816 | We have recently identified the interaction between netrin-4 (NTN4) and integrin beta-4 (ITGB4), which promotes glioblastoma cell proliferation via activating AKT-mTOR signaling pathway |
| 24265816 | We have recently identified the interaction between netrin-4 (NTN4) and integrin beta-4 (ITGB4), which promotes glioblastoma cell proliferation via activating AKT-mTOR signaling pathway |
| 24265816 | In the current work we have explored the effect of NTN4/ITGB4 interaction on TMZ induced glioblastoma cell senescence |
| 24265816 | We report here that the suppression of either ITGB4 or NTN4 in glioblastoma cell lines significantly enhances cellular senescence |
| 24265816 | NTN4 partially inhibited TMZ induced cell senescence and rescued AKT from dephosphorylation in U251MG cells, a cell line bearing decent levels of ITGB4 |
| 24265816 | However, addition of exogenous NTN4 displayed no significant effect on TMZ induced senescence rescue or AKT activation in U87MG cells, which expressed ITGB4 at low levels |
| 24265816 | Furthermore, overexpression of ITGB4 combined with exogenous NTN4 significantly attenuated U87MG cell senescence induced by TMZ |
| 24265816 | These data suggest that NTN4 protects glioblastoma cells from TMZ induced senescence, probably via rescuing TMZ triggered ITGB4 dependent AKT dephosphorylation |
| 24265816 | This suggests that interfering the interaction between NTN4 and ITGB4 or concomitant use of the inhibitors of the AKT pathway may improve the therapeutic efficiency of TMZ |
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