HCSGD entry for ACE2

1. General information

Official gene symbolACE2
Entrez ID59272
Gene full nameangiotensin I converting enzyme (peptidyl-dipeptidase A) 2
Other gene symbolsACEH
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001618Virus receptor activityIDAmolecular_function
GO:0001817Regulation of cytokine productionICbiological_process
GO:0001948Glycoprotein bindingIPImolecular_function
GO:0002003Angiotensin maturationTASbiological_process
GO:0002005Angiotensin catabolic process in bloodICbiological_process
GO:0003051Angiotensin-mediated drinking behaviorIMPbiological_process
GO:0003081Regulation of systemic arterial blood pressure by renin-angiotensinIC IMPbiological_process
GO:0004175Endopeptidase activityIDAmolecular_function
GO:0004180Carboxypeptidase activityIDAmolecular_function
GO:0005576Extracellular regionIDAcellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0008237Metallopeptidase activityIDAmolecular_function
GO:0008241Peptidyl-dipeptidase activityIDAmolecular_function
GO:0008270Zinc ion bindingTASmolecular_function
GO:0009615Response to virusIDAbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0017046Peptide hormone bindingIEAmolecular_function
GO:0019229Regulation of vasoconstrictionICbiological_process
GO:0032800Receptor biosynthetic processIMPbiological_process
GO:0042127Regulation of cell proliferationTASbiological_process
GO:0042312Regulation of vasodilationICbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0045121Membrane raftTAScellular_component
GO:0046718Viral entry into host cellTASbiological_process
GO:0046813Receptor-mediated virion attachment to host cellIDAbiological_process
GO:0050727Regulation of inflammatory responseICbiological_process
GO:2000379Positive regulation of reactive oxygen species metabolic processICbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.63658656210.93302165570.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0412990206
GSE13712_SHEARUp0.1048269898
GSE13712_STATICUp0.0058020783
GSE19018Up0.1849882059
GSE19899_A1Up0.0581781119
GSE19899_A2Up0.1155014866
PubMed_21979375_A1Up0.0943826741
PubMed_21979375_A2Up0.0561132423
GSE35957Up0.1644632631
GSE36640Up0.0019486206
GSE54402Up0.0791847035
GSE9593Up0.0931367752
GSE43922Up0.0165708790
GSE24585Down-0.2256996317
GSE37065Up0.0532017800
GSE28863_A1Up0.0133592316
GSE28863_A2Down-0.0200889113
GSE28863_A3Up0.1262926927
GSE28863_A4Up0.0203213706
GSE48662Down-0.0455220556

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

MoexiprilDB00691 APRD01120
LisinoprilDB00722 APRD00560
SPP1148DB05203 -
TAK-491DB05358 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT030157MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27146690Here we test this hypothesis by synthetically creating unicellular derivatives of snowflake yeast through functional complementation with the ancestral ACE2 allele
22283774However, the new view of RAS, points to the ACE2/Ang-(1-7)/Mas receptor axis as a counter-regulator of the effects of the classic Ang II-mediated effects
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