HCSGD entry for RASA1

1. General information

Official gene symbolRASA1
Entrez ID5921
Gene full nameRAS p21 protein activator (GTPase activating protein) 1
Other gene symbolsCM-AVM CMAVM GAP PKWS RASA RASGAP p120GAP p120RASGAP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000281Mitotic cytokinesisISSbiological_process
GO:0001570VasculogenesisISSbiological_process
GO:0001726RuffleIEAcellular_component
GO:0001948Glycoprotein bindingIPImolecular_function
GO:0001953Negative regulation of cell-matrix adhesionIDAbiological_process
GO:0005099Ras GTPase activator activityIBA IEAmolecular_function
GO:0005102Receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005737CytoplasmIBA NAScellular_component
GO:0005829CytosolTAScellular_component
GO:0007162Negative regulation of cell adhesionIDAbiological_process
GO:0007165Signal transductionIDA IEAbiological_process
GO:0008360Regulation of cell shapeNASbiological_process
GO:0009790Embryo developmentISSbiological_process
GO:0019870Potassium channel inhibitor activityNASmolecular_function
GO:0030833Regulation of actin filament polymerizationIDAbiological_process
GO:0031235Intrinsic component of the cytoplasmic side of the plasma membraneIBAcellular_component
GO:0032320Positive regulation of Ras GTPase activityIBAbiological_process
GO:0035556Intracellular signal transductionNASbiological_process
GO:0043524Negative regulation of neuron apoptotic processISSbiological_process
GO:0046580Negative regulation of Ras protein signal transductionIBA IEAbiological_process
GO:0051020GTPase bindingIPImolecular_function
GO:0051252Regulation of RNA metabolic processNASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01637531630.62914269970.31492352081.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3391784649
GSE13712_SHEARUp0.1740912544
GSE13712_STATICUp0.0666288799
GSE19018Down-0.4172509661
GSE19899_A1Up1.2239253686
GSE19899_A2Up0.2877820338
PubMed_21979375_A1Up1.3143074614
PubMed_21979375_A2Up0.8936732220
GSE35957Down-0.5122988130
GSE36640Up1.0395301410
GSE54402Up0.1547982812
GSE9593Up0.2003556979
GSE43922Up0.9938080599
GSE24585Up0.1823426976
GSE37065Down-0.1439458938
GSE28863_A1Up0.0863002067
GSE28863_A2Up0.1413765034
GSE28863_A3Down-0.9016306856
GSE28863_A4Down-0.2258599743
GSE48662Down-0.0628483587

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT003230Luciferase reporter assayNon-Functional MTI20065103
hsa-miR-132-3pMIMAT0000426MIRT007010Immunoblot//Western blotFunctional MTI21868695
hsa-miR-31-5pMIMAT0000089MIRT007292Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI23322774
hsa-miR-214-3pMIMAT0000271MIRT024963Microarray;OtherFunctional MTI (Weak)19859982
hsa-miR-30c-5pMIMAT0000244MIRT047898CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049006CLASHFunctional MTI (Weak)23622248
hsa-miR-26a-5pMIMAT0000082MIRT050067CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.