HCSGD entry for RARS
1. General information
| Official gene symbol | RARS |
|---|---|
| Entrez ID | 5917 |
| Gene full name | arginyl-tRNA synthetase |
| Other gene symbols | ArgRS DALRD1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000049 | TRNA binding | IEA | molecular_function |
| GO:0004814 | Arginine-tRNA ligase activity | IEA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006418 | TRNA aminoacylation for protein translation | TAS | biological_process |
| GO:0006420 | Arginyl-tRNA aminoacylation | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0017101 | Aminoacyl-tRNA synthetase multienzyme complex | IEA | cellular_component |
| GO:0034618 | Arginine binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9294841191 | 0.1124489191 | 0.9999902473 | 0.6425896657 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2713206113 |
| GSE13712_SHEAR | Down | -0.0997543534 |
| GSE13712_STATIC | Up | 0.0649795972 |
| GSE19018 | Down | -0.5619445940 |
| GSE19899_A1 | Up | 0.0482784469 |
| GSE19899_A2 | Down | -0.1592795245 |
| PubMed_21979375_A1 | Up | 0.1602455812 |
| PubMed_21979375_A2 | Up | 0.0502129376 |
| GSE35957 | Up | 0.0044075538 |
| GSE36640 | Down | -0.0992296596 |
| GSE54402 | Up | 0.0721652583 |
| GSE9593 | Down | -0.1195663024 |
| GSE43922 | Down | -0.0142593571 |
| GSE24585 | Down | -0.3471526979 |
| GSE37065 | Down | -0.2196168618 |
| GSE28863_A1 | Down | -0.1676674926 |
| GSE28863_A2 | Up | 0.1645237036 |
| GSE28863_A3 | Down | -0.7859830471 |
| GSE28863_A4 | Up | 0.0308533393 |
| GSE48662 | Down | -0.3552680762 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT001423 | Northern blot//qRT-PCR | Functional MTI (Weak) | 12434020 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT001423 | pSILAC//Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT001423 | qRT-PCR | Functional MTI (Weak) | 15648093 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT001423 | Microarray | Functional MTI (Weak) | 21199864 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020669 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT036949 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043075 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043276 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048431 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048622 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049812 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26774567 | Our results showed that DR micelles moderately inhibited MCF-7 breast cancer cell growth through inducing p21-associated cellular senescence, which relied on retinoic acid receptors (RARs) and was accompanied by significant G0/G1 cell cycle arrest |
| 7628539 | The nuclear receptors for retinoic acid are of two types, the initially described RARs, and the RXRs |
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