HCSGD entry for RARG

1. General information

Official gene symbolRARG
Entrez ID5916
Gene full nameretinoic acid receptor, gamma
Other gene symbolsNR1B3 RARC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEA ISSbiological_process
GO:0003430Growth plate cartilage chondrocyte growthIEAbiological_process
GO:0003677DNA bindingIEA ISSmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityISSmolecular_function
GO:0003707Steroid hormone receptor activityIEAmolecular_function
GO:0003708Retinoic acid receptor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEA ISScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIEA ISScellular_component
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008285Negative regulation of cell proliferationIEA ISSbiological_process
GO:0008361Regulation of cell sizeTASbiological_process
GO:0009952Anterior/posterior pattern specificationIEAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016021Integral component of membraneNAScellular_component
GO:0031641Regulation of myelinationIEAbiological_process
GO:0032331Negative regulation of chondrocyte differentiationIEAbiological_process
GO:0032526Response to retinoic acidIDAbiological_process
GO:0035116Embryonic hindlimb morphogenesisIEA ISSbiological_process
GO:0035264Multicellular organism growthIEAbiological_process
GO:0043065Positive regulation of apoptotic processIEA ISSbiological_process
GO:0043068Positive regulation of programmed cell deathISSbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEA ISSbiological_process
GO:0046965Retinoid X receptor bindingIEA ISSmolecular_function
GO:0048048Embryonic eye morphogenesisIEA ISSbiological_process
GO:0048384Retinoic acid receptor signaling pathwayIDAbiological_process
GO:0060070Canonical Wnt signaling pathwayTASbiological_process
GO:0060534Trachea cartilage developmentIEAbiological_process
GO:0060740Prostate gland epithelium morphogenesisIEAbiological_process
GO:0061037Negative regulation of cartilage developmentIEAbiological_process
GO:0070384Harderian gland developmentIEAbiological_process
GO:0071300Cellular response to retinoic acidIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.45093957680.43513762020.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0717028135
GSE13712_SHEARUp0.2612574715
GSE13712_STATICDown-0.1047637518
GSE19018Up0.0282721628
GSE19899_A1Down-0.0194673550
GSE19899_A2Up0.0611398480
PubMed_21979375_A1Down-0.5014751685
PubMed_21979375_A2Down-0.0877429342
GSE35957Down-0.1512442511
GSE36640Up0.2820303323
GSE54402Down-0.1466502097
GSE9593Up0.1459543297
GSE43922Down-0.0955306225
GSE24585Up0.3529269157
GSE37065Down-0.0486472236
GSE28863_A1Up0.6074863216
GSE28863_A2Up0.0619287207
GSE28863_A3Down-0.5539037027
GSE28863_A4Up0.0171831470
GSE48662Up0.1471234869

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AdapaleneDB00210 APRD00780
TazaroteneDB00799 APRD01246
EtretinateDB00926 APRD00966
SR11254DB02258 EXPT00094
4-[3-Oxo-3-(5,5,8,8-Tetramethyl-5,6,7,8-Tetrahydro-Naphthalen-2-Yl)-Propenyl]-Benzoic AcidDB02466 EXPT00042
CD564DB02741 EXPT00233
Dodecyl-Alpha-D-MaltosideDB03279 EXPT02044
BMS184394DB03466 EXPT00057
R667DB05467 -
LGD-1550DB05785 -
R-3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACIDDB07031 -
3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACIDDB07294 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-182-5pMIMAT0000259MIRT001222Luciferase reporter assay//Western blotFunctional MTI19782699
hsa-miR-124-3pMIMAT0000422MIRT002564Microarray//Microarray;OtherFunctional MTI (Weak)15685193
hsa-miR-335-5pMIMAT0000765MIRT017251MicroarrayFunctional MTI (Weak)18185580
hsa-miR-320cMIMAT0005793MIRT036166CLASHFunctional MTI (Weak)23622248
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-182-5pMIMAT0000259NAhsa-miR-182{Western blot}{overexpression by miRNA mimics tranfection}19782699
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19782699In addition, we identified retinoic acid receptor gamma (RARG) as a target of miR-182 and showed that this protein was down-regulated during SIPS in HDF and HTM cells
19782699These results suggest that changes in miRNA expression might contribute to phenotypic alterations of senescent cells by modulating the expression of key regulatory proteins such as p21(CDKN1A) as well as by targeting genes that are down-regulated in senescent cells such as RARG
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