HCSGD entry for RARB
1. General information
| Official gene symbol | RARB |
|---|---|
| Entrez ID | 5915 |
| Gene full name | retinoic acid receptor, beta |
| Other gene symbols | HAP NR1B2 RRB2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0001657 | Ureteric bud development | IEA | biological_process |
| GO:0003417 | Growth plate cartilage development | IEA | biological_process |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0003707 | Steroid hormone receptor activity | IEA | molecular_function |
| GO:0003708 | Retinoic acid receptor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0008144 | Drug binding | IEA | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0021756 | Striatum development | IEA | biological_process |
| GO:0031641 | Regulation of myelination | IEA | biological_process |
| GO:0032331 | Negative regulation of chondrocyte differentiation | IEA | biological_process |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0035116 | Embryonic hindlimb morphogenesis | IEA | biological_process |
| GO:0035264 | Multicellular organism growth | IEA | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045666 | Positive regulation of neuron differentiation | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0046965 | Retinoid X receptor binding | IEA | molecular_function |
| GO:0048048 | Embryonic eye morphogenesis | IEA | biological_process |
| GO:0048566 | Embryonic digestive tract development | IMP | biological_process |
| GO:0055012 | Ventricular cardiac muscle cell differentiation | IEA | biological_process |
| GO:0061037 | Negative regulation of cartilage development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5610711067 | 0.4655418259 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1668751385 |
| GSE13712_SHEAR | Up | 0.4632555380 |
| GSE13712_STATIC | Up | 0.2608515373 |
| GSE19018 | Down | -0.0310743428 |
| GSE19899_A1 | Up | 0.0091926675 |
| GSE19899_A2 | Up | 0.0635386700 |
| PubMed_21979375_A1 | Up | 0.1613261408 |
| PubMed_21979375_A2 | Up | 0.0801695694 |
| GSE35957 | Down | -0.4272808554 |
| GSE36640 | Up | 0.1036271558 |
| GSE54402 | Up | 0.0434056287 |
| GSE9593 | Down | -0.0305318882 |
| GSE43922 | Up | 0.3893815285 |
| GSE24585 | Down | -0.3472208131 |
| GSE37065 | Down | -0.2313903442 |
| GSE28863_A1 | Down | -0.0240632516 |
| GSE28863_A2 | Down | -0.3074010326 |
| GSE28863_A3 | Up | 0.2524805490 |
| GSE28863_A4 | Down | -0.0598705071 |
| GSE48662 | Down | -0.0252860885 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Adapalene | DB00210 | APRD00780 |
| Tazarotene | DB00799 | APRD01246 |
| Etretinate | DB00926 | APRD00966 |
| TTNPB | DB02877 | EXPT03128 |
| Tamibarotene | DB04942 | - |
| LGD-1550 | DB05785 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-2-3p | MIMAT0004518 | MIRT004488 | qRT-PCR//Western blot | Functional MTI | 20309880 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25997921 | Retinoids induce cellular senescence in breast cancer cells by RAR-beta dependent and independent pathways: Potential clinical implications (Review) |
| 23430755 | By double labeling of senescent cells, first by SA-beta-Gal and then by antibodies against genes related to cellular senescence, we found that p21, p16, and RARbeta, but not p53, were upregulated by bexarotene in mammary tumors and in breast cancer cell lines, suggesting involvement of multiple signaling pathways in mediating the senescence program of rexinoids |
| 21843507 | These effects were mediated by retinoic acid receptor beta(2) whose promoter was also hypomethylated in the presence of ATRA |
| 19650165 | Novel information is provided about the role of retinoic acid receptor beta 5 (RARbeta5) in mediating the retinoid-induced senescent program |
| 18673301 | Specific ligands of RAR-beta can potentially be used in anti-cancer therapy |
| 18673301 | RT-PCR (reverse transcription-PCR) and Western blot analyses show that HRPE cells specifically express only RAR-beta and none of the other receptor subtypes |
| 18673301 | In addition, we show that the expression of RAR-beta increases with increasing passage number of the cells |
| 18673301 | Interestingly, the increase in RAR-beta expression is not associated with telomere shortening, a typical biomarker of cellular senescence |
| 18673301 | In the present study, we also describe a protocol for characterizing RAR-beta-ligand interactions using nuclear extract from late passage HRPE cells as a source of endogenous RAR-beta |
| 18673301 | Using [(3)H]CD367 as the ligand, RAR-beta in HRPE cells showed an affinity of 9 |
| 18673301 | We have confirmed the feasibility of using this assay to detect the interaction of ligands with RAR-beta by investigating the ability of certain flavonoids to inhibit the binding of [(3)H]CD367 to nuclear extracts from HRPE cells |
| 18673301 | The inhibition constant of the flavonoids for RAR-beta was between approx |
| 18673301 | 1-30 microM, showing that the flavonoids interact with RAR-beta with low affinity |
| 17168722 | Among these target genes, the RARbeta gene is of great interest, being able to encode a potential tumour suppressor |
| 17168722 | It should be emphasized that most breast carcinomas and breast cancer cell lines show loss or down-regulation of RARbeta receptor expression, whereas RARalpha and gamma, as well as retinoid X receptors, appear to be variably expressed in both normal and tumour cells |
| 17168722 | It is also interesting to note that basal and RA-induced RARbeta mRNA levels tend to increase with senescence of normal cells |
| 17168722 | The aim of this review is to clarify whether expression of RARbeta could be modulated by chemopreventive intervention and may therefore serve as an intermediate biomarker in chemoprevention trials for some cancers |
| 7737367 | Cellular aging and transformation suppression: a role for retinoic acid receptor beta 2 |
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