HCSGD entry for RARA

1. General information

Official gene symbolRARA
Entrez ID5914
Gene full nameretinoic acid receptor, alpha
Other gene symbolsNR1B1 RAR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0000790Nuclear chromatinIDAcellular_component
GO:0000900Translation repressor activity, nucleic acid bindingIEAmolecular_function
GO:0001657Ureteric bud developmentIEAbiological_process
GO:0001889Liver developmentIEAbiological_process
GO:0001972Retinoic acid bindingIDAmolecular_function
GO:0003417Growth plate cartilage developmentIEAbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003707Steroid hormone receptor activityIEAmolecular_function
GO:0003708Retinoic acid receptor activityIDA IEAmolecular_function
GO:0003713Transcription coactivator activityIDA IMPmolecular_function
GO:0003714Transcription corepressor activityIDAmolecular_function
GO:0005102Receptor bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006468Protein phosphorylationIMPbiological_process
GO:0007165Signal transductionIDAbiological_process
GO:0007281Germ cell developmentIEAbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0007565Female pregnancyIEAbiological_process
GO:0008134Transcription factor bindingIEA IPImolecular_function
GO:0008144Drug bindingIEAmolecular_function
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008284Positive regulation of cell proliferationIEA IMPbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0009986Cell surfaceICcellular_component
GO:0010467Gene expressionTASbiological_process
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIEAbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0019904Protein domain specific bindingIPImolecular_function
GO:0030425DendriteIEAcellular_component
GO:0030520Intracellular estrogen receptor signaling pathwayIDAbiological_process
GO:0030850Prostate gland developmentIEAbiological_process
GO:0030852Regulation of granulocyte differentiationIEAbiological_process
GO:0030853Negative regulation of granulocyte differentiationIDAbiological_process
GO:0031490Chromatin DNA bindingIDAmolecular_function
GO:0031641Regulation of myelinationIEAbiological_process
GO:0032355Response to estradiolIDA IEAbiological_process
GO:0032526Response to retinoic acidIEA IMPbiological_process
GO:0032689Negative regulation of interferon-gamma productionIDAbiological_process
GO:0032720Negative regulation of tumor necrosis factor productionIDAbiological_process
GO:0032736Positive regulation of interleukin-13 productionIDAbiological_process
GO:0032753Positive regulation of interleukin-4 productionIDAbiological_process
GO:0032754Positive regulation of interleukin-5 productionIDAbiological_process
GO:0033189Response to vitamin AIEAbiological_process
GO:0034097Response to cytokineIEAbiological_process
GO:0035014Phosphatidylinositol 3-kinase regulator activityIEAmolecular_function
GO:0035264Multicellular organism growthIEAbiological_process
GO:0042981Regulation of apoptotic processIEAbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043277Apoptotic cell clearanceIMPbiological_process
GO:0043422Protein kinase B bindingIPImolecular_function
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIEAmolecular_function
GO:0044323Retinoic acid-responsive element bindingIDAmolecular_function
GO:0045471Response to ethanolIEAbiological_process
GO:0045596Negative regulation of cell differentiationIEAbiological_process
GO:0045630Positive regulation of T-helper 2 cell differentiationIDAbiological_process
GO:0045666Positive regulation of neuron differentiationIEAbiological_process
GO:0045787Positive regulation of cell cycleIMPbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA IMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0045947Negative regulation of translational initiationIEAbiological_process
GO:0046982Protein heterodimerization activityIDAmolecular_function
GO:0048027MRNA 5'-UTR bindingIEAmolecular_function
GO:0048167Regulation of synaptic plasticityIEAbiological_process
GO:0048384Retinoic acid receptor signaling pathwayIMPbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0051018Protein kinase A bindingIDAmolecular_function
GO:0051099Positive regulation of bindingIMPbiological_process
GO:0051897Positive regulation of protein kinase B signalingIEAbiological_process
GO:0055012Ventricular cardiac muscle cell differentiationIEAbiological_process
GO:0060010Sertoli cell fate commitmentIEAbiological_process
GO:0060591Chondroblast differentiationIEAbiological_process
GO:0061037Negative regulation of cartilage developmentIEAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0071222Cellular response to lipopolysaccharideIEAbiological_process
GO:0071300Cellular response to retinoic acidIDAbiological_process
GO:0071391Cellular response to estrogen stimulusIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.42962305760.84270472630.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2143893781
GSE13712_SHEARUp0.0564703078
GSE13712_STATICDown-0.0702938328
GSE19018Down-0.0142533144
GSE19899_A1Up0.0696009691
GSE19899_A2Up0.3258408891
PubMed_21979375_A1Up0.1571311507
PubMed_21979375_A2Up0.4787509148
GSE35957Down-0.1360742706
GSE36640Up0.0850403156
GSE54402Up0.0043519700
GSE9593Down-0.2166657949
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.6374156189

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AdapaleneDB00210 APRD00780
TazaroteneDB00799 APRD01246
EtretinateDB00926 APRD00966
IsotretinoinDB00982 APRD00140
TamibaroteneDB04942 -
LGD-1550DB05785 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-125a-5pMIMAT0000443MIRT004389Microarray//Northern blotFunctional MTI (Weak)16331254
hsa-miR-218-5pMIMAT0000275MIRT024237SequencingFunctional MTI (Weak)20371350
hsa-miR-615-3pMIMAT0003283MIRT039873CLASHFunctional MTI (Weak)23622248
hsa-miR-138-5pMIMAT0000430MIRT045829CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.