HCSGD entry for RAP1B

1. General information

Official gene symbolRAP1B
Entrez ID5908
Gene full nameRAP1B, member of RAS oncogene family
Other gene symbolsK-REV RAL1B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003924GTPase activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005525GTP bindingIDA IEAmolecular_function
GO:0005622IntracellularIDAcellular_component
GO:0005769Early endosomeIEAcellular_component
GO:0005770Late endosomeIEAcellular_component
GO:0005811Lipid particleIDAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005911Cell-cell junctionIDAcellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0007264Small GTPase mediated signal transductionIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008283Cell proliferationIEAbiological_process
GO:0010976Positive regulation of neuron projection developmentIEAbiological_process
GO:0016020MembraneIEA TAScellular_component
GO:0017016Ras GTPase bindingIEAmolecular_function
GO:0017034Rap guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0019003GDP bindingIDAmolecular_function
GO:0030054Cell junctionIEAcellular_component
GO:0030168Platelet activationTASbiological_process
GO:0032045Guanyl-nucleotide exchange factor complexIEAcellular_component
GO:0032403Protein complex bindingIDAmolecular_function
GO:0032486Rap protein signal transductionIMPbiological_process
GO:0032854Positive regulation of Rap GTPase activityIEAbiological_process
GO:0038180Nerve growth factor signaling pathwayIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045860Positive regulation of protein kinase activityIEAbiological_process
GO:0050796Regulation of insulin secretionTASbiological_process
GO:0061028Establishment of endothelial barrierIMPbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0071320Cellular response to cAMPIDAbiological_process
GO:1901888Regulation of cell junction assemblyIMPbiological_process
GO:2000114Regulation of establishment of cell polarityIMPbiological_process
GO:2001214Positive regulation of vasculogenesisIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.79303921200.27348196500.99999024730.9997665000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1284686093
GSE13712_SHEARDown-0.0081553237
GSE13712_STATICDown-0.0241379501
GSE19018Down-0.1763310538
GSE19899_A1Up0.1179646191
GSE19899_A2Down-0.0716843049
PubMed_21979375_A1Up0.1979018510
PubMed_21979375_A2Up0.0666055305
GSE35957Down-0.1378993435
GSE36640Down-0.0812464697
GSE54402Up0.1158841197
GSE9593Down-0.0650164147
GSE43922Down-0.0258929965
GSE24585Down-0.0832285292
GSE37065Down-0.0023384533
GSE28863_A1Up0.1080130590
GSE28863_A2Down-0.7240643079
GSE28863_A3Down-0.3934518388
GSE28863_A4Up0.2424770091
GSE48662Down-0.1339628303

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-518bMIMAT0002844MIRT006853Luciferase reporter assayFunctional MTI22958893
hsa-miR-155-5pMIMAT0000646MIRT020552ProteomicsFunctional MTI (Weak)18668040
hsa-miR-1MIMAT0000416MIRT023540ProteomicsFunctional MTI (Weak)18668040
hsa-miR-26b-5pMIMAT0000083MIRT028850MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.