HCSGD entry for RAP1A

1. General information

Official gene symbolRAP1A
Entrez ID5906
Gene full nameRAP1A, member of RAS oncogene family
Other gene symbolsKREV-1 KREV1 RAP1 SMGP21
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000186Activation of MAPKK activityTASbiological_process
GO:0003924GTPase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005769Early endosomeISScellular_component
GO:0005770Late endosomeISScellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008565Protein transporter activityIDAmolecular_function
GO:0010976Positive regulation of neuron projection developmentISSbiological_process
GO:0015031Protein transportIDAbiological_process
GO:0017016Ras GTPase bindingIEAmolecular_function
GO:0017034Rap guanyl-nucleotide exchange factor activityISSmolecular_function
GO:0030054Cell junctionISScellular_component
GO:0030168Platelet activationTASbiological_process
GO:0032045Guanyl-nucleotide exchange factor complexIEAcellular_component
GO:0032403Protein complex bindingIDAmolecular_function
GO:0032486Rap protein signal transductionIMPbiological_process
GO:0032854Positive regulation of Rap GTPase activityISSbiological_process
GO:0038180Nerve growth factor signaling pathwayISSbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045860Positive regulation of protein kinase activityISSbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0050796Regulation of insulin secretionTASbiological_process
GO:0061028Establishment of endothelial barrierIMPbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:0071320Cellular response to cAMPIDAbiological_process
GO:1901888Regulation of cell junction assemblyIMPbiological_process
GO:1990090Cellular response to nerve growth factor stimulusISSbiological_process
GO:2001214Positive regulation of vasculogenesisISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.51322906040.46218194600.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0487078103
GSE13712_SHEARDown-0.2389562810
GSE13712_STATICDown-0.0727877712
GSE19018Down-0.1416206072
GSE19899_A1Up0.1023558252
GSE19899_A2Up3.6849393803
PubMed_21979375_A1Down-0.1957151742
PubMed_21979375_A2Down-0.1049889588
GSE35957Up0.1437590994
GSE36640Up0.2434462374
GSE54402Up0.0290611464
GSE9593Down-0.1637919625
GSE43922Down-0.0330449464
GSE24585Down-0.1452773026
GSE37065Up0.0423824193
GSE28863_A1Up0.0498438505
GSE28863_A2Up0.2625696973
GSE28863_A3Down-0.2527590128
GSE28863_A4Down-0.1696150929
GSE48662Down-0.2999340850

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-337-3pMIMAT0000754MIRT006958Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22723956
hsa-let-7e-5pMIMAT0000066MIRT051421CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.