HCSGD entry for RANGAP1
1. General information
| Official gene symbol | RANGAP1 |
|---|---|
| Entrez ID | 5905 |
| Gene full name | Ran GTPase activating protein 1 |
| Other gene symbols | Fug1 SD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0000776 | Kinetochore | IDA | cellular_component |
| GO:0000777 | Condensed chromosome kinetochore | IEA | cellular_component |
| GO:0000922 | Spindle pole | IEA | cellular_component |
| GO:0005098 | Ran GTPase activator activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005643 | Nuclear pore | TAS | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0031965 | Nuclear membrane | IEA | cellular_component |
| GO:0032320 | Positive regulation of Ras GTPase activity | TAS | biological_process |
| GO:0032853 | Positive regulation of Ran GTPase activity | TAS | biological_process |
| GO:0043085 | Positive regulation of catalytic activity | TAS | biological_process |
| GO:0043547 | Positive regulation of GTPase activity | TAS | biological_process |
| GO:0046826 | Negative regulation of protein export from nucleus | IDA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0050790 | Regulation of catalytic activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1549175525 | 0.0819764941 | 0.7823455295 | 0.5429283061 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3868737017 |
| GSE13712_SHEAR | Up | 0.7099917582 |
| GSE13712_STATIC | Up | 0.4959361284 |
| GSE19018 | Up | 0.1196575276 |
| GSE19899_A1 | Down | -0.9490111272 |
| GSE19899_A2 | Up | 0.2535248484 |
| PubMed_21979375_A1 | Up | 0.7056540085 |
| PubMed_21979375_A2 | Down | -1.7632219989 |
| GSE35957 | Down | -0.1104573273 |
| GSE36640 | Down | -0.0561367027 |
| GSE54402 | Down | -0.6015944333 |
| GSE9593 | Up | 0.2199191301 |
| GSE43922 | Up | 0.0060320619 |
| GSE24585 | Down | -0.3431513402 |
| GSE37065 | Down | -0.0428479814 |
| GSE28863_A1 | Down | -0.3240453613 |
| GSE28863_A2 | Down | -0.2045305282 |
| GSE28863_A3 | Up | 0.2474062253 |
| GSE28863_A4 | Up | 0.2037098048 |
| GSE48662 | Up | 0.0401996149 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT031630 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1301-3p | MIMAT0005797 | MIRT036035 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043425 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049661 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-31-5p | MIMAT0000089 | MIRT049887 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
