HCSGD entry for RALA

1. General information

Official gene symbolRALA
Entrez ID5898
Gene full namev-ral simian leukemia viral oncogene homolog A (ras related)
Other gene symbolsRAL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000910CytokinesisIDAbiological_process
GO:0003924GTPase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005886Plasma membraneIDA IEAcellular_component
GO:0006887ExocytosisIEAbiological_process
GO:0006935ChemotaxisTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007265Ras protein signal transductionIEA TASbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0016032Viral processIEAbiological_process
GO:0017157Regulation of exocytosisIDA IEAbiological_process
GO:0030139Endocytic vesicleIDAcellular_component
GO:0030496MidbodyIEAcellular_component
GO:0030659Cytoplasmic vesicle membraneTAScellular_component
GO:0031532Actin cytoskeleton reorganizationIDAbiological_process
GO:0031755Edg-2 lysophosphatidic acid receptor bindingIDAmolecular_function
GO:0032154Cleavage furrowIDAcellular_component
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051491Positive regulation of filopodium assemblyIDAbiological_process
GO:0051665Membrane raft localizationIDA IEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00410079020.86741013260.17269904001.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.7028087454
GSE13712_SHEARDown-0.4152209964
GSE13712_STATICDown-0.4625736735
GSE19018Up0.6303872434
GSE19899_A1Up1.6054377008
GSE19899_A2Up1.3015488326
PubMed_21979375_A1Up1.5300443502
PubMed_21979375_A2Up1.2823190009
GSE35957Up0.1334888631
GSE36640Down-0.1547944402
GSE54402Up0.5170144658
GSE9593Up0.5849222343
GSE43922Up0.9896999428
GSE24585Down-0.0196105144
GSE37065Up0.0655725227
GSE28863_A1Down-0.1082538504
GSE28863_A2Down-0.4615184513
GSE28863_A3Up0.2126410070
GSE28863_A4Up0.0223607975
GSE48662Down-0.1911915763

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Guanosine-5'-DiphosphateDB04315 EXPT01573

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-181a-5pMIMAT0000256MIRT006194Flow//Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI22442671
hsa-miR-24-3pMIMAT0000080MIRT030612MicroarrayFunctional MTI (Weak)19748357
hsa-miR-186-5pMIMAT0000456MIRT045096CLASHFunctional MTI (Weak)23622248
hsa-miR-7-5pMIMAT0000252MIRT047767CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

2594886336]) but were greater in the combined PI arms than in the RAL arm (spine: -3
11080532Senescent HDF cells as well as V12S35 and V12G37 expressers were unable to export actin fibers from nucleus to cytoplasm, form stress fibers through the MAPK and Ral
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