HCSGD entry for RAG2
1. General information
| Official gene symbol | RAG2 |
|---|---|
| Entrez ID | 5897 |
| Gene full name | recombination activating gene 2 |
| Other gene symbols | RAG-2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002326 | B cell lineage commitment | IEA | biological_process |
| GO:0002331 | Pre-B cell allelic exclusion | IEA ISS | biological_process |
| GO:0002358 | B cell homeostatic proliferation | IEA | biological_process |
| GO:0002360 | T cell lineage commitment | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003682 | Chromatin binding | IEA ISS | molecular_function |
| GO:0005546 | Phosphatidylinositol-4,5-bisphosphate binding | IEA ISS | molecular_function |
| GO:0005547 | Phosphatidylinositol-3,4,5-trisphosphate binding | IEA ISS | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0008270 | Zinc ion binding | IEA ISS | molecular_function |
| GO:0016568 | Chromatin modification | IEA | biological_process |
| GO:0030183 | B cell differentiation | ISS | biological_process |
| GO:0033077 | T cell differentiation in thymus | IEA ISS | biological_process |
| GO:0033151 | V(D)J recombination | IEA ISS | biological_process |
| GO:0035064 | Methylated histone residue binding | IEA ISS | molecular_function |
| GO:0035091 | Phosphatidylinositol binding | ISS | molecular_function |
| GO:0043325 | Phosphatidylinositol-3,4-bisphosphate binding | IEA ISS | molecular_function |
| GO:0046622 | Positive regulation of organ growth | IEA | biological_process |
| GO:0080025 | Phosphatidylinositol-3,5-bisphosphate binding | IEA ISS | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7010220546 | 0.7713062080 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0636512865 |
| GSE13712_SHEAR | Down | -0.0073452706 |
| GSE13712_STATIC | Up | 0.0233606484 |
| GSE19018 | Down | -0.0319908370 |
| GSE19899_A1 | Up | 0.0604293317 |
| GSE19899_A2 | Up | 0.1443221465 |
| PubMed_21979375_A1 | Up | 0.1114374156 |
| PubMed_21979375_A2 | Down | -0.2045969768 |
| GSE35957 | Up | 0.1079283374 |
| GSE36640 | Down | -0.0451438828 |
| GSE54402 | Down | -0.0049803582 |
| GSE9593 | Up | 0.3055859108 |
| GSE43922 | Down | -0.0032395873 |
| GSE24585 | Up | 0.0388722184 |
| GSE37065 | Down | -0.0235704443 |
| GSE28863_A1 | Up | 0.0161834093 |
| GSE28863_A2 | Down | -0.0420970291 |
| GSE28863_A3 | Up | 0.1217356061 |
| GSE28863_A4 | Down | -0.0128932687 |
| GSE48662 | Down | -0.0738740703 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22689960 | Helicobacter hepaticus-infected Rag2(-/-) mice emulate many aspects of human inflammatory bowel disease, including the development of colitis and colon cancer |
| 20331441 | Unexpectedly, the accumulation of damaged cells was found to occur independent from the DNA damage response modulator p53, and from an intact immune system, as their levels were similar in wild-type and Rag2(-/-) gammaC(-/-) mice, the latter being deficient in T, B, and NK cells |
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