HCSGD entry for RAD51C
1. General information
| Official gene symbol | RAD51C |
|---|---|
| Entrez ID | 5889 |
| Gene full name | RAD51 homolog C (S. cerevisiae) |
| Other gene symbols | BROVCA3 FANCO RAD51L2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0006259 | DNA metabolic process | IEA | biological_process |
| GO:0006281 | DNA repair | IDA | biological_process |
| GO:0006310 | DNA recombination | IDA | biological_process |
| GO:0007062 | Sister chromatid cohesion | ISS | biological_process |
| GO:0007066 | Female meiosis sister chromatid cohesion | IEA | biological_process |
| GO:0007131 | Reciprocal meiotic recombination | IEA | biological_process |
| GO:0007141 | Male meiosis I | IEA | biological_process |
| GO:0007283 | Spermatogenesis | IEA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008094 | DNA-dependent ATPase activity | IEA | molecular_function |
| GO:0008821 | Crossover junction endodeoxyribonuclease activity | IEA | molecular_function |
| GO:0048471 | Perinuclear region of cytoplasm | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4036343034 | 0.0865570343 | 0.9999902473 | 0.5585358421 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2595082205 |
| GSE13712_SHEAR | Up | 0.5195807115 |
| GSE13712_STATIC | Up | 0.6096922397 |
| GSE19018 | Up | 0.0037162736 |
| GSE19899_A1 | Down | -0.1846875291 |
| GSE19899_A2 | Down | -0.9405592707 |
| PubMed_21979375_A1 | Up | 0.1558678446 |
| PubMed_21979375_A2 | Down | -1.1172365713 |
| GSE35957 | Down | -0.9257680794 |
| GSE36640 | Down | -0.8597759267 |
| GSE54402 | Down | -0.2208004099 |
| GSE9593 | Down | -0.7413431065 |
| GSE43922 | Up | 0.0338664997 |
| GSE24585 | Up | 0.4832369690 |
| GSE37065 | Down | -0.2021641867 |
| GSE28863_A1 | Up | 0.1860101395 |
| GSE28863_A2 | Up | 0.1693283967 |
| GSE28863_A3 | Up | 0.1614584950 |
| GSE28863_A4 | Down | -0.0318808976 |
| GSE48662 | Down | -0.2327712212 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT000897 | Microarray | Functional MTI (Weak) | 18362358 |
| hsa-miR-15a-5p | MIMAT0000068 | MIRT000898 | Microarray | Functional MTI (Weak) | 18362358 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029315 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048598 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048689 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-15a-5p | MIMAT0000068 | NA | hsa-miR-15a | 18362358 | |||
| hsa-miR-16-5p | MIMAT0000069 | NA | hsa-miR-16 | 18362358 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26820992 | Rad51c recombination-deficient breast cancers |
| 26820992 | Rad51c is one of the key mediators of HR and a well-known BC predisposition gene |
| 26820992 | Here, we demonstrate that deletion of Rad51c invariably requires inactivation of the Trp53 tumor suppressor (TP53 in humans) to produce mammary carcinomas in 63% of female mice |
| 26820992 | Similar to other BC models, Rad51c/p53 double-mutant mouse mammary tumors also reveal a propensity for genomic instability, but lack the focal amplification of the Met locus or distinct mutational signatures reported for other HR genes |
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