HCSGD entry for RAD51

1. General information

Official gene symbolRAD51
Entrez ID5888
Gene full nameRAD51 homolog (S. cerevisiae)
Other gene symbolsBRCC5 HRAD51 HsRad51 HsT16930 MRMV2 RAD51A RECA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000166Nucleotide bindingIEAmolecular_function
GO:0000228Nuclear chromosomeIDAcellular_component
GO:0000724Double-strand break repair via homologous recombinationIDA IEA IMP TASbiological_process
GO:0000730DNA recombinase assemblyTASbiological_process
GO:0000793Condensed chromosomeISScellular_component
GO:0000794Condensed nuclear chromosomeISScellular_component
GO:0000800Lateral elementIEAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0003684Damaged DNA bindingIEAmolecular_function
GO:0003690Double-stranded DNA bindingIDAmolecular_function
GO:0003697Single-stranded DNA bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005634NucleusIDA ISScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIDAcellular_component
GO:0005759Mitochondrial matrixIEAcellular_component
GO:0006200ATP catabolic processIDAbiological_process
GO:0006268DNA unwinding involved in DNA replicationIDAbiological_process
GO:0006281DNA repairIEA TASbiological_process
GO:0006302Double-strand break repairTASbiological_process
GO:0006310DNA recombinationTASbiological_process
GO:0006312Mitotic recombinationTASbiological_process
GO:0006974Cellular response to DNA damage stimulusIDAbiological_process
GO:0007126MeiosisIEA ISSbiological_process
GO:0007131Reciprocal meiotic recombinationTASbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0008094DNA-dependent ATPase activityIEAmolecular_function
GO:0010569Regulation of double-strand break repair via homologous recombinationIDAbiological_process
GO:0016605PML bodyIDAcellular_component
GO:0042802Identical protein bindingIPImolecular_function
GO:0043142Single-stranded DNA-dependent ATPase activityIDAmolecular_function
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0051106Positive regulation of DNA ligationIDAbiological_process
GO:0051260Protein homooligomerizationIPIbiological_process
GO:0071479Cellular response to ionizing radiationIDAbiological_process
GO:0072757Cellular response to camptothecinIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.97837525170.00040987420.99999024730.0380348592

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3199190798
GSE13712_SHEARUp0.1858859696
GSE13712_STATICDown-0.3796754902
GSE19018Down-0.2200838840
GSE19899_A1Down-0.4660386129
GSE19899_A2Down-2.0451151195
PubMed_21979375_A1Down-0.9428567963
PubMed_21979375_A2Down-2.2514630194
GSE35957Down-1.6003038528
GSE36640Down-2.9929699382
GSE54402Down-0.5849252867
GSE9593Down-0.7527350949
GSE43922Down-1.2300108969
GSE24585Down-0.0531167488
GSE37065Down-0.7371655739
GSE28863_A1Down-0.3339183154
GSE28863_A2Up0.6765513332
GSE28863_A3Up0.0596000941
GSE28863_A4Up0.2017512155
GSE48662Down-1.5349897720

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Phosphoaminophosphonic Acid-Adenylate EsterDB04395 EXPT00524
MP470DB05216 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-197-3pMIMAT0000227MIRT003819MicroarrayFunctional MTI (Weak)16822819
hsa-miR-193b-3pMIMAT0002819MIRT016582MicroarrayFunctional MTI (Weak)20304954
hsa-miR-124-3pMIMAT0000422MIRT023031MicroarrayFunctional MTI (Weak)18668037
hsa-miR-215-5pMIMAT0000272MIRT024626MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026888MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026888SequencingFunctional MTI (Weak)20371350
hsa-miR-103a-3pMIMAT0000101MIRT027144SequencingFunctional MTI (Weak)20371350
hsa-miR-92a-1-5pMIMAT0004507MIRT038926CLASHFunctional MTI (Weak)23622248
hsa-miR-23b-3pMIMAT0000418MIRT046358CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 7 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24814484In particular, isw2Delta cells show an increased response to genotoxic stresses, and the DNA repair enzyme Rad51 is important for isw2Delta-mediated longevity
24615016Superresolution microscopy reveals that all PML bodies within a nucleus are engaged at Rad51- and RPA-containing repair foci during ongoing DNA repair
24615016Thus, while PML NBs specifically accumulate at Rad51/RPA-containing lesions and senescence-derived persistent DNA damage foci, they are not essential for DNA damage-induced and replicative senescence of human and murine fibroblasts
23383259Studies with mismatch repair mutants and MSH6, Rad51 and ATM knockdowns revealed that autophagy induced by O(6)MeG requires mismatch repair and ATM, and is counteracted by homologous recombination
21118958Unlike transient foci, DNA-SCARS associate with PML nuclear bodies, lack the DNA repair proteins RPA and RAD51, lack single-stranded DNA and DNA synthesis and accumulate activated forms of the DDR mediators CHK2 and p53
15779908We show that human telomeric strand-exchange complexes mediated by Escherichia coli RecA protein differ from those formed with nontelomeric sequences
15779908We propose that the strong DNA unwinding activity inherent in the assembly of the RecA strand-exchange complex promotes the formation of alternative DNA structures at human telomeric loci
12748277The Rad51 pathway of telomerase-independent maintenance of telomeres can amplify TG1-3 sequences in yku and cdc13 mutants of Saccharomyces cerevisiae
12748277Strikingly, inactivation of the Rad50/Rad59 pathway (which is normally required for type II recombination) in cdc13-1 yku70delta or yku70delta tlc1delta mutants, but also in cdc13-1 YKU70(+) tlc1delta mutants, still permitted type II recombination, but this process was now entirely dependent on the Rad51 pathway
12748277These results demonstrate that in wild-type cells, masking by Cdc13 and Yku prevents the Rad51 pathway from amplifying telomeric TG(1-3) sequences
12748277They also suggest that Rad51 is more efficient than Rad50 in amplifying the sequences left uncovered by the absence of Cdc13 or Yku70
11181991Notable features presently include four enzymes that can remove uracil from DNA, seven recombination genes related to RAD51, and many recently discovered DNA polymerases that bypass damage, but only one system to remove the main DNA lesions induced by ultraviolet light
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