HCSGD entry for RAB27A
1. General information
| Official gene symbol | RAB27A |
|---|---|
| Entrez ID | 5873 |
| Gene full name | RAB27A, member RAS oncogene family |
| Other gene symbols | GS2 HsT18676 RAB27 RAM |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001750 | Photoreceptor outer segment | IEA | cellular_component |
| GO:0003924 | GTPase activity | IEA ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA ISS | molecular_function |
| GO:0005764 | Lysosome | IDA | cellular_component |
| GO:0005770 | Late endosome | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0006605 | Protein targeting | IEA | biological_process |
| GO:0006887 | Exocytosis | IDA | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | IEA | biological_process |
| GO:0007596 | Blood coagulation | IEA | biological_process |
| GO:0016324 | Apical plasma membrane | IEA | cellular_component |
| GO:0019003 | GDP binding | IDA | molecular_function |
| GO:0019904 | Protein domain specific binding | IEA | molecular_function |
| GO:0030318 | Melanocyte differentiation | IEA | biological_process |
| GO:0030425 | Dendrite | IDA | cellular_component |
| GO:0030667 | Secretory granule membrane | IEA | cellular_component |
| GO:0031489 | Myosin V binding | IEA | molecular_function |
| GO:0032402 | Melanosome transport | IEA | biological_process |
| GO:0032585 | Multivesicular body membrane | IDA | cellular_component |
| GO:0042470 | Melanosome | IDA IEA | cellular_component |
| GO:0043316 | Cytotoxic T cell degranulation | IEA | biological_process |
| GO:0043320 | Natural killer cell degranulation | IEA | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0045921 | Positive regulation of exocytosis | IMP | biological_process |
| GO:0070382 | Exocytic vesicle | IDA | cellular_component |
| GO:0071985 | Multivesicular body sorting pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9674460697 | 0.0187838798 | 0.9999902473 | 0.2689224035 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4378849296 |
| GSE13712_SHEAR | Down | -0.5402083302 |
| GSE13712_STATIC | Up | 0.0474046126 |
| GSE19018 | Down | -0.4443423836 |
| GSE19899_A1 | Down | -0.4006504975 |
| GSE19899_A2 | Down | -0.4944669364 |
| PubMed_21979375_A1 | Up | 0.0031544033 |
| PubMed_21979375_A2 | Down | -0.0077430108 |
| GSE35957 | Down | -0.4087085544 |
| GSE36640 | Down | -1.8059146893 |
| GSE54402 | Down | -0.1235332224 |
| GSE9593 | Up | 0.0921811981 |
| GSE43922 | Down | -0.0917445262 |
| GSE24585 | Up | 0.3026811485 |
| GSE37065 | Down | -0.0605150123 |
| GSE28863_A1 | Up | 0.2420959252 |
| GSE28863_A2 | Down | -0.0569255130 |
| GSE28863_A3 | Down | -0.4318805159 |
| GSE28863_A4 | Up | 0.0260187292 |
| GSE48662 | Down | -0.6365149668 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022236 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024773 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026172 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028890 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23991634 | The CREB-dependent reduction in RAB27A coding for the Ras-related protein Rab27A and IGFBP3 coding for the insulin-like growth factor-binding protein 3 has been confirmed for aged lung tissue, senescent fibroblasts, and lung epithelial cells on AGE-modified collagen |
| 23991634 | Our data demonstrate that the reduced protein expression of CREB might play a significant role in lung aging by modifying the transcription of RAB27A, IGFBP3, and other target genes |
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