HCSGD entry for BCAT1
1. General information
| Official gene symbol | BCAT1 |
|---|---|
| Entrez ID | 586 |
| Gene full name | branched chain amino-acid transaminase 1, cytosolic |
| Other gene symbols | BCATC BCT1 ECA39 MECA39 PNAS121 PP18 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0004084 | Branched-chain-amino-acid transaminase activity | EXP | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0009082 | Branched-chain amino acid biosynthetic process | IEA | biological_process |
| GO:0009083 | Branched-chain amino acid catabolic process | TAS | biological_process |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0042802 | Identical protein binding | IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0052654 | L-leucine transaminase activity | IEA | molecular_function |
| GO:0052655 | L-valine transaminase activity | IEA | molecular_function |
| GO:0052656 | L-isoleucine transaminase activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7125869686 | 0.0023820600 | 0.9999902473 | 0.0948535552 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5582690775 |
| GSE13712_SHEAR | Down | -0.1012029161 |
| GSE13712_STATIC | Down | -0.4353774240 |
| GSE19018 | Up | 0.9157147945 |
| GSE19899_A1 | Down | -0.4358829681 |
| GSE19899_A2 | Down | -0.7035066519 |
| PubMed_21979375_A1 | Down | -1.4890810573 |
| PubMed_21979375_A2 | Down | -1.4195741672 |
| GSE35957 | Up | 0.7118671602 |
| GSE36640 | Down | -0.4816682139 |
| GSE54402 | Down | -0.3162049600 |
| GSE9593 | Down | -0.1436709623 |
| GSE43922 | Down | -0.4657529958 |
| GSE24585 | Down | -1.6011136105 |
| GSE37065 | Up | 0.3202888380 |
| GSE28863_A1 | Up | 0.3302304549 |
| GSE28863_A2 | Down | -0.5239965510 |
| GSE28863_A3 | Down | -0.6288118048 |
| GSE28863_A4 | Up | 0.2141238223 |
| GSE48662 | Down | -0.1519616321 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Glutamic Acid | DB00142 | NUTR00027 |
| L-Leucine | DB00149 | NUTR00033 |
| L-Valine | DB00161 | NUTR00060 |
| L-Isoleucine | DB00167 | NUTR00031 |
| N'-(5-CHLOROBENZOFURAN-2-CARBONYL)-2-(TRIFLUOROMETHYL)BENZENESULFONOHYDRAZIDE | DB07544 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT004088 | Microarray | Functional MTI (Weak) | 19193853 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028360 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030880 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-769-5p | MIMAT0003886 | MIRT039195 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052293 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052384 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
