HCSGD entry for CACTIN

1. General information

Official gene symbolCACTIN
Entrez ID58509
Gene full namecactin, spliceosome C complex subunit
Other gene symbolsC19orf29 NY-REN-24 fSAPc
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000398MRNA splicing, via spliceosomeICbiological_process
GO:0001933Negative regulation of protein phosphorylationIMPbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0031665Negative regulation of lipopolysaccharide-mediated signaling pathwayIMPbiological_process
GO:0032088Negative regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0032688Negative regulation of interferon-beta productionIMPbiological_process
GO:0032717Negative regulation of interleukin-8 productionIDAbiological_process
GO:0032720Negative regulation of tumor necrosis factor productionIDAbiological_process
GO:0034122Negative regulation of toll-like receptor signaling pathwayIDAbiological_process
GO:0045087Innate immune responseIEAbiological_process
GO:0060339Negative regulation of type I interferon-mediated signaling pathwayIMPbiological_process
GO:0071013Catalytic step 2 spliceosomeIDAcellular_component
GO:0071222Cellular response to lipopolysaccharideIDAbiological_process
GO:0071347Cellular response to interleukin-1IDAbiological_process
GO:0071356Cellular response to tumor necrosis factorIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.60586250900.79300310780.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0781156783
GSE13712_SHEARUp0.0710381366
GSE13712_STATICDown-0.0258394488
GSE19018Up0.0462489816
GSE19899_A1Up0.0287465074
GSE19899_A2Up0.2985269844
PubMed_21979375_A1Up0.1058847528
PubMed_21979375_A2Up0.2503323458
GSE35957Down-0.1363655426
GSE36640Up0.0673647207
GSE54402Up0.0066831973
GSE9593Down-0.0817316105
GSE43922Up0.0472128297
GSE24585Down-0.0604284982
GSE37065Down-0.2954451366
GSE28863_A1Down-0.0101977083
GSE28863_A2Down-0.1321568394
GSE28863_A3Up0.3032324241
GSE28863_A4Up0.0832017368
GSE48662Up0.1769147420

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-378a-5pMIMAT0000731MIRT043985CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.