HCSGD entry for ALDH18A1
1. General information
| Official gene symbol | ALDH18A1 |
|---|---|
| Entrez ID | 5832 |
| Gene full name | aldehyde dehydrogenase 18 family, member A1 |
| Other gene symbols | ARCL3A GSAS P5CS PYCS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004349 | Glutamate 5-kinase activity | IDA | molecular_function |
| GO:0004350 | Glutamate-5-semialdehyde dehydrogenase activity | IDA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | TAS | cellular_component |
| GO:0006536 | Glutamate metabolic process | IMP | biological_process |
| GO:0006561 | Proline biosynthetic process | IMP | biological_process |
| GO:0006592 | Ornithine biosynthetic process | IMP | biological_process |
| GO:0008652 | Cellular amino acid biosynthetic process | TAS | biological_process |
| GO:0019240 | Citrulline biosynthetic process | IMP | biological_process |
| GO:0034641 | Cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0055129 | L-proline biosynthetic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9939034611 | 0.0044297443 | 0.9999902473 | 0.1354076037 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4540647669 |
| GSE13712_SHEAR | Down | -0.2360193685 |
| GSE13712_STATIC | Down | -0.1046268506 |
| GSE19018 | Down | -0.1535415261 |
| GSE19899_A1 | Down | -0.9159823778 |
| GSE19899_A2 | Down | -0.8261080953 |
| PubMed_21979375_A1 | Down | -1.0389579805 |
| PubMed_21979375_A2 | Down | -0.1853006370 |
| GSE35957 | Down | -0.1383833579 |
| GSE36640 | Down | -0.5160498471 |
| GSE54402 | Down | -0.1441531159 |
| GSE9593 | Down | -0.3523716527 |
| GSE43922 | Down | -0.2192719659 |
| GSE24585 | Down | -0.6885635675 |
| GSE37065 | Down | -0.6077134956 |
| GSE28863_A1 | Up | 0.2659914161 |
| GSE28863_A2 | Up | 0.3946347031 |
| GSE28863_A3 | Down | -0.5602954624 |
| GSE28863_A4 | Up | 0.0503489490 |
| GSE48662 | Down | -0.5924189574 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Glutamic Acid | DB00142 | NUTR00027 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022930 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031825 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037662 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT050486 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
