HCSGD entry for PVRL2

1. General information

Official gene symbolPVRL2
Entrez ID5819
Gene full namepoliovirus receptor-related 2 (herpesvirus entry mediator B)
Other gene symbolsCD112 HVEB PRR2 PVRR2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001618Virus receptor activityIEAmolecular_function
GO:0001675Acrosome assemblyIEAbiological_process
GO:0002860Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetIMPbiological_process
GO:0002891Positive regulation of immunoglobulin mediated immune responseIMPbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005911Cell-cell junctionIDAcellular_component
GO:0005915Zonula adherensISScellular_component
GO:0007010Cytoskeleton organizationIEAbiological_process
GO:0007156Homophilic cell adhesionIDAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007286Spermatid developmentISSbiological_process
GO:0007289Spermatid nucleus differentiationIEAbiological_process
GO:0009566FertilizationIEAbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0015026Coreceptor activityTASmolecular_function
GO:0016021Integral component of membraneIDAcellular_component
GO:0019064Fusion of virus membrane with host plasma membraneIDAbiological_process
GO:0030382Sperm mitochondrion organizationIEAbiological_process
GO:0032990Cell part morphogenesisIEAbiological_process
GO:0033005Positive regulation of mast cell activationIMPbiological_process
GO:0034329Cell junction assemblyTASbiological_process
GO:0034332Adherens junction organizationTASbiological_process
GO:0042271Susceptibility to natural killer cell mediated cytotoxicityIMPbiological_process
GO:0042803Protein homodimerization activityIEA IPImolecular_function
GO:0044782Cilium organizationIEAbiological_process
GO:0045216Cell-cell junction organizationTASbiological_process
GO:0045954Positive regulation of natural killer cell mediated cytotoxicityIMPbiological_process
GO:0046814Coreceptor-mediated virion attachment to host cellIDAbiological_process
GO:0050776Regulation of immune responseTASbiological_process
GO:0050839Cell adhesion molecule bindingIPImolecular_function
GO:0051654Establishment of mitochondrion localizationIEAbiological_process
GO:0051856Adhesion to symbiontIDAbiological_process
GO:0060370Susceptibility to T cell mediated cytotoxicityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.87110083580.05248072640.99999024730.4316703750

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4040339154
GSE13712_SHEARUp0.0357343800
GSE13712_STATICUp0.3227989132
GSE19018Up0.0000266667
GSE19899_A1Down-0.5086925678
GSE19899_A2Up0.2016583532
PubMed_21979375_A1Down-0.0731910981
PubMed_21979375_A2Down-0.2812353575
GSE35957Down-0.2959489950
GSE36640Down-0.3240845444
GSE54402Down-1.0891573849
GSE9593Up0.0961357577
GSE43922Down-0.0272192981
GSE24585Down-0.2603184796
GSE37065Up0.2919678072
GSE28863_A1Up0.0771122122
GSE28863_A2Down-0.0587447134
GSE28863_A3Down-0.0461942953
GSE28863_A4Down-0.0355066909
GSE48662Up0.2324495067

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018722MicroarrayFunctional MTI (Weak)18185580
hsa-miR-320aMIMAT0000510MIRT044500CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.