HCSGD entry for PVR
1. General information
| Official gene symbol | PVR |
|---|---|
| Entrez ID | 5817 |
| Gene full name | poliovirus receptor |
| Other gene symbols | CD155 HVED NECL5 Necl-5 PVS TAGE4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001618 | Virus receptor activity | IEA | molecular_function |
| GO:0002860 | Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target | IMP | biological_process |
| GO:0004872 | Receptor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005615 | Extracellular space | TAS | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0016021 | Integral component of membrane | IDA | cellular_component |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016337 | Cell-cell adhesion | IEA | biological_process |
| GO:0016477 | Cell migration | IEA | biological_process |
| GO:0030054 | Cell junction | IDA | cellular_component |
| GO:0034329 | Cell junction assembly | TAS | biological_process |
| GO:0034332 | Adherens junction organization | TAS | biological_process |
| GO:0042271 | Susceptibility to natural killer cell mediated cytotoxicity | IMP | biological_process |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0045216 | Cell-cell junction organization | TAS | biological_process |
| GO:0045954 | Positive regulation of natural killer cell mediated cytotoxicity | IMP | biological_process |
| GO:0050776 | Regulation of immune response | TAS | biological_process |
| GO:0050839 | Cell adhesion molecule binding | IPI | molecular_function |
| GO:0060370 | Susceptibility to T cell mediated cytotoxicity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0253393222 | 0.4954320391 | 0.3736850420 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0503492897 |
| GSE13712_SHEAR | Up | 1.2565181430 |
| GSE13712_STATIC | Up | 0.8762414751 |
| GSE19018 | Up | 0.1000622742 |
| GSE19899_A1 | Down | -0.3153487419 |
| GSE19899_A2 | Up | 1.1182471950 |
| PubMed_21979375_A1 | Up | 1.7589671698 |
| PubMed_21979375_A2 | Down | -0.1972544701 |
| GSE35957 | Up | 0.2471375253 |
| GSE36640 | Up | 0.8548241326 |
| GSE54402 | Down | -0.6999556297 |
| GSE9593 | Up | 0.1634203818 |
| GSE43922 | Up | 0.5928448647 |
| GSE24585 | Down | -0.4923879031 |
| GSE37065 | Down | -0.2675306039 |
| GSE28863_A1 | Down | -0.1756644685 |
| GSE28863_A2 | Up | 0.2289574680 |
| GSE28863_A3 | Down | -0.2227472012 |
| GSE28863_A4 | Up | 0.0855890581 |
| GSE48662 | Up | 0.3024765180 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT031973 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032490 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040310 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27853638 | Melphalan treatment was able to enhance the surface expression of the stress-induced NKG2D ligands RAE-1 and MULT-1, and of the DNAM-1 ligand PVR (CD155) on MM cells, leading to better tumor cell recognition and killing by NK cells, as highlighted by NK cell increased degranulation triggered by melphalan-treated tumor cells |
| 27853638 | Furthermore, we showed that low doses of melphalan fail to induce tumor cell apoptosis, but promote the in vivo establishment of a senescent tumor cell population, harboring high levels of the stress-induced ligands RAE-1 and PVR |
| 24913980 | Drug-induced MICA and PVR gene expression are transcriptionally regulated and involve DDR-dependent E2F1 transcription factor activity |
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