HCSGD entry for PTBP2


1. General information

Official gene symbolPTBP2
Entrez ID58155
Gene full namepolypyrimidine tract binding protein 2
Other gene symbolsPTB PTBLP brPTB nPTB nPTB5 nPTB6 nPTB7 nPTB8
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000166Nucleotide bindingIEAmolecular_function
GO:0003723RNA bindingIEAmolecular_function
GO:0003729MRNA bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005681Spliceosomal complexIEAcellular_component
GO:0006376MRNA splice site selectionIEAbiological_process
GO:0006397MRNA processingIEAbiological_process
GO:0033119Negative regulation of RNA splicingIDAbiological_process
GO:2000177Regulation of neural precursor cell proliferationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.86868652790.00293607390.99999024730.1080917483

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.7211423109
GSE13712_SHEARDown-0.4809826506
GSE13712_STATICDown-0.3401913146
GSE19018Down-0.2903211002
GSE19899_A1Down-0.3334578996
GSE19899_A2Down-2.1201211377
PubMed_21979375_A1Down-0.9180875064
PubMed_21979375_A2Down-1.7444075969
GSE35957Down-0.6669892412
GSE36640Down-1.0935198513
GSE54402Down-0.2437827771
GSE9593Down-0.5143530239
GSE43922Down-0.7754900224
GSE24585Down-0.1752779386
GSE37065Up0.0078092340
GSE28863_A1Up0.5970782058
GSE28863_A2Up0.9284843730
GSE28863_A3Down-0.4960120661
GSE28863_A4Down-0.3693247329
GSE48662Down-0.6170532553

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT001344pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-133bMIMAT0000770MIRT003052Reporter assayFunctional MTI17210790
hsa-miR-215-5pMIMAT0000272MIRT024340MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026877MicroarrayFunctional MTI (Weak)19074876
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-133bMIMAT00007702hsa-miR-133b{Western blot}{Western blot}{underexpression by LNA antisense miRNA oligonucleotides}{mutation}17210790
hsa-miR-133bMIMAT00007701hsa-miR-133b{Western blot}{Western blot}{underexpression by LNA antisense miRNA oligonucleotides}{mutation}17210790
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27363602Here, we assess whether expression changes of key splicing regulator genes and consequent effects on alternative splicing are also associated with strain longevity in old and young mice, across 6 different mouse strains with varying lifespan (A/J, NOD
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