HCSGD entry for PTBP2
1. General information
Official gene symbol | PTBP2 |
---|---|
Entrez ID | 58155 |
Gene full name | polypyrimidine tract binding protein 2 |
Other gene symbols | PTB PTBLP brPTB nPTB nPTB5 nPTB6 nPTB7 nPTB8 |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network

This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0000166 | Nucleotide binding | IEA | molecular_function |
GO:0003723 | RNA binding | IEA | molecular_function |
GO:0003729 | MRNA binding | IEA | molecular_function |
GO:0005634 | Nucleus | IEA | cellular_component |
GO:0005681 | Spliceosomal complex | IEA | cellular_component |
GO:0006376 | MRNA splice site selection | IEA | biological_process |
GO:0006397 | MRNA processing | IEA | biological_process |
GO:0033119 | Negative regulation of RNA splicing | IDA | biological_process |
GO:2000177 | Regulation of neural precursor cell proliferation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.8686865279 | 0.0029360739 | 0.9999902473 | 0.1080917483 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Up | 0.7211423109 |
GSE13712_SHEAR | Down | -0.4809826506 |
GSE13712_STATIC | Down | -0.3401913146 |
GSE19018 | Down | -0.2903211002 |
GSE19899_A1 | Down | -0.3334578996 |
GSE19899_A2 | Down | -2.1201211377 |
PubMed_21979375_A1 | Down | -0.9180875064 |
PubMed_21979375_A2 | Down | -1.7444075969 |
GSE35957 | Down | -0.6669892412 |
GSE36640 | Down | -1.0935198513 |
GSE54402 | Down | -0.2437827771 |
GSE9593 | Down | -0.5143530239 |
GSE43922 | Down | -0.7754900224 |
GSE24585 | Down | -0.1752779386 |
GSE37065 | Up | 0.0078092340 |
GSE28863_A1 | Up | 0.5970782058 |
GSE28863_A2 | Up | 0.9284843730 |
GSE28863_A3 | Down | -0.4960120661 |
GSE28863_A4 | Down | -0.3693247329 |
GSE48662 | Down | -0.6170532553 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
---|---|---|---|---|---|
hsa-miR-1 | MIMAT0000416 | MIRT001344 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
hsa-miR-133b | MIMAT0000770 | MIRT003052 | Reporter assay | Functional MTI | 17210790 |
hsa-miR-215-5p | MIMAT0000272 | MIRT024340 | Microarray | Functional MTI (Weak) | 19074876 |
hsa-miR-192-5p | MIMAT0000222 | MIRT026877 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
---|---|---|---|---|---|---|---|
hsa-miR-133b | MIMAT0000770 | 2 | hsa-miR-133b | {Western blot}{Western blot} | {underexpression by LNA antisense miRNA oligonucleotides}{mutation} | 17210790 | |
hsa-miR-133b | MIMAT0000770 | 1 | hsa-miR-133b | {Western blot}{Western blot} | {underexpression by LNA antisense miRNA oligonucleotides}{mutation} | 17210790 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
---|---|
27363602 | Here, we assess whether expression changes of key splicing regulator genes and consequent effects on alternative splicing are also associated with strain longevity in old and young mice, across 6 different mouse strains with varying lifespan (A/J, NOD |
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