HCSGD entry for BARD1

1. General information

Official gene symbolBARD1
Entrez ID580
Gene full nameBRCA1 associated RING domain 1
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000151Ubiquitin ligase complexNAScellular_component
GO:0001894Tissue homeostasisTASbiological_process
GO:0003723RNA bindingIDAmolecular_function
GO:0004842Ubiquitin-protein ligase activityIDA NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IMPcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006281DNA repairIEAbiological_process
GO:0006974Cellular response to DNA damage stimulusNASbiological_process
GO:0007050Cell cycle arrestNASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0016567Protein ubiquitinationNASbiological_process
GO:0019900Kinase bindingNASmolecular_function
GO:0031436BRCA1-BARD1 complexIDAcellular_component
GO:0031441Negative regulation of mRNA 3'-end processingNASbiological_process
GO:0042325Regulation of phosphorylationIMPbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043065Positive regulation of apoptotic processIMPbiological_process
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0045732Positive regulation of protein catabolic processNASbiological_process
GO:0046826Negative regulation of protein export from nucleusIDAbiological_process
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0070531BRCA1-A complexIDAcellular_component
GO:0085020Protein K6-linked ubiquitinationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99831501080.00002335400.99999024730.0085375000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.7137575736
GSE13712_SHEARDown-0.6570268950
GSE13712_STATICDown-0.5248498957
GSE19018Down-0.5756317328
GSE19899_A1Down-0.6928401625
GSE19899_A2Down-3.8509517708
PubMed_21979375_A1Down-2.3259496890
PubMed_21979375_A2Down-3.7486556873
GSE35957Down-2.1417585917
GSE36640Down-3.1406735445
GSE54402Down-0.9585354364
GSE9593Down-1.2240526096
GSE43922Down-2.5236698501
GSE24585Up0.3043374048
GSE37065Up0.0382325102
GSE28863_A1Down-0.1556556090
GSE28863_A2Up0.0492636808
GSE28863_A3Down-0.8759018231
GSE28863_A4Down-0.1172795731
GSE48662Down-1.4729106375

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-192-5pMIMAT0000222MIRT004138MicroarrayFunctional MTI (Weak)16822819
hsa-miR-192-5pMIMAT0000222MIRT004138MicroarrayFunctional MTI (Weak)19074876
hsa-miR-193b-3pMIMAT0002819MIRT016283MicroarrayFunctional MTI (Weak)20304954
hsa-miR-215-5pMIMAT0000272MIRT024951MicroarrayFunctional MTI (Weak)19074876
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.