HCSGD entry for PTPRM

1. General information

Official gene symbolPTPRM
Entrez ID5797
Gene full nameprotein tyrosine phosphatase, receptor type, M
Other gene symbolsPTPRL1 R-PTP-MU RPTPM RPTPU hR-PTPu
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001937Negative regulation of endothelial cell proliferationIMPbiological_process
GO:0004725Protein tyrosine phosphatase activityIDA IEAmolecular_function
GO:0005001Transmembrane receptor protein tyrosine phosphatase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005887Integral component of plasma membraneNAScellular_component
GO:0005911Cell-cell junctionIDAcellular_component
GO:0005913Cell-cell adherens junctionIDAcellular_component
GO:0006470Protein dephosphorylationIDAbiological_process
GO:0007156Homophilic cell adhesionIDAbiological_process
GO:0007165Signal transductionIDAbiological_process
GO:0010596Negative regulation of endothelial cell migrationIMPbiological_process
GO:0010842Retina layer formationIMPbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016525Negative regulation of angiogenesisIMPbiological_process
GO:0030027LamellipodiumIDAcellular_component
GO:0031175Neuron projection developmentIDA IMPbiological_process
GO:0031290Retinal ganglion cell axon guidanceIDAbiological_process
GO:0035335Peptidyl-tyrosine dephosphorylationIDAbiological_process
GO:0042493Response to drugIDAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0045296Cadherin bindingIDAmolecular_function
GO:0045909Positive regulation of vasodilationIEAbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.34474019980.05676900950.99999024730.4474859707

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3885780455
GSE13712_SHEARDown-0.2474079247
GSE13712_STATICDown-0.2946030769
GSE19018Up0.3335231964
GSE19899_A1Down-0.9150383248
GSE19899_A2Down-0.8648025105
PubMed_21979375_A1Up0.1732370904
PubMed_21979375_A2Down-0.2894550746
GSE35957Up0.6466132894
GSE36640Up1.7275796478
GSE54402Down-0.7709821198
GSE9593Up0.3169546907
GSE43922Down-0.7384516790
GSE24585Down-0.0133840329
GSE37065Up0.1165116648
GSE28863_A1Up0.1212458274
GSE28863_A2Up0.2137287714
GSE28863_A3Down-0.1020790654
GSE28863_A4Up0.0254896136
GSE48662Up0.0700553338

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018602MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.