HCSGD entry for PTPRJ

1. General information

Official gene symbolPTPRJ
Entrez ID5795
Gene full nameprotein tyrosine phosphatase, receptor type, J
Other gene symbolsCD148 DEP1 HPTPeta R-PTP-ETA SCC1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001570VasculogenesisIEAbiological_process
GO:0001772Immunological synapseIDAcellular_component
GO:0004725Protein tyrosine phosphatase activityIDA IMPmolecular_function
GO:0005161Platelet-derived growth factor receptor bindingIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneIDAcellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0005911Cell-cell junctionIDAcellular_component
GO:0007507Heart developmentIEAbiological_process
GO:0007596Blood coagulationIEAbiological_process
GO:0008013Beta-catenin bindingIPImolecular_function
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010572Positive regulation of platelet activationIEAbiological_process
GO:0010642Negative regulation of platelet-derived growth factor receptor signaling pathwayIDAbiological_process
GO:0010759Positive regulation of macrophage chemotaxisIEAbiological_process
GO:0016791Phosphatase activityIDA IMPmolecular_function
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030155Regulation of cell adhesionIMPbiological_process
GO:0030308Negative regulation of cell growthIDAbiological_process
GO:0030336Negative regulation of cell migrationIDAbiological_process
GO:0032587Ruffle membraneIEAcellular_component
GO:0035335Peptidyl-tyrosine dephosphorylationIDA IMPbiological_process
GO:0042059Negative regulation of epidermal growth factor receptor signaling pathwayIMPbiological_process
GO:0043116Negative regulation of vascular permeabilityIDAbiological_process
GO:0043407Negative regulation of MAP kinase activityIDAbiological_process
GO:0045295Gamma-catenin bindingIPImolecular_function
GO:0045785Positive regulation of cell adhesionIMPbiological_process
GO:0048008Platelet-derived growth factor receptor signaling pathwayIMPbiological_process
GO:0050860Negative regulation of T cell receptor signaling pathwayIDA IMPbiological_process
GO:0050918Positive chemotaxisIDAbiological_process
GO:0051019Mitogen-activated protein kinase bindingIPImolecular_function
GO:0051894Positive regulation of focal adhesion assemblyIMPbiological_process
GO:0051897Positive regulation of protein kinase B signalingIMPbiological_process
GO:0051898Negative regulation of protein kinase B signalingIMPbiological_process
GO:0060242Contact inhibitionNASbiological_process
GO:0070097Delta-catenin bindingIPImolecular_function
GO:2000272Negative regulation of receptor activityIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.72459321450.20348300980.99999024730.8736739726

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4026724318
GSE13712_SHEARUp0.1002720110
GSE13712_STATICUp0.3452455060
GSE19018Up0.3131768190
GSE19899_A1Up0.0398413711
GSE19899_A2Up0.0680685385
PubMed_21979375_A1Up0.0637289454
PubMed_21979375_A2Down-0.1815942231
GSE35957Up0.0470303992
GSE36640Up0.1742772352
GSE54402Down-0.2411788364
GSE9593Down-0.2859883167
GSE43922Up0.0545050511
GSE24585Down-0.5172861078
GSE37065Up0.4152173197
GSE28863_A1Down-0.0585340135
GSE28863_A2Up0.1455273461
GSE28863_A3Down-0.6243657054
GSE28863_A4Up0.0287942369
GSE48662Down-0.2615338257

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-328-3pMIMAT0000752MIRT006477qRT-PCR//Western blotFunctional MTI22564856
hsa-miR-155-5pMIMAT0000646MIRT001514pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-335-5pMIMAT0000765MIRT017530MicroarrayFunctional MTI (Weak)18185580
hsa-miR-124-3pMIMAT0000422MIRT022460MicroarrayFunctional MTI (Weak)18668037
hsa-miR-26b-5pMIMAT0000083MIRT029278MicroarrayFunctional MTI (Weak)19088304
hsa-miR-16-5pMIMAT0000069MIRT031605ProteomicsFunctional MTI (Weak)18668040
hsa-miR-31-5pMIMAT0000089MIRT049863CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25412306We identified 107 proteins that could be potential markers of senescence and validated 10 of them (DEP1, NTAL, EBP50, STX4, VAMP3, ARMX3, B2MG, LANCL1, VPS26A and PLD3)
25412306We demonstrated that a combination of these proteins can be used to specifically recognize senescent cells in culture and in tissue samples and we developed a straightforward fluorescence-activated cell sorting-based detection approach using two of them (DEP1 and B2MG)
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