HCSGD entry for PTPRB

1. General information

Official gene symbolPTPRB
Entrez ID5787
Gene full nameprotein tyrosine phosphatase, receptor type, B
Other gene symbolsHPTP-BETA HPTPB PTPB R-PTP-BETA VEPTP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEAbiological_process
GO:0004725Protein tyrosine phosphatase activityIEAmolecular_function
GO:0005001Transmembrane receptor protein tyrosine phosphatase activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006470Protein dephosphorylationTASbiological_process
GO:0006796Phosphate-containing compound metabolic processTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0016311DephosphorylationIDAbiological_process
GO:0035335Peptidyl-tyrosine dephosphorylationTASbiological_process
GO:0043235Receptor complexIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.63962942140.02511360510.99999024730.3050370097

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1798527673
GSE13712_SHEARDown-0.1928840519
GSE13712_STATICUp0.0004837945
GSE19018Up0.4459187715
GSE19899_A1Down-0.0108250119
GSE19899_A2Down-0.1567537987
PubMed_21979375_A1Down-0.3976702244
PubMed_21979375_A2Down-0.7473590055
GSE35957Up0.7630025301
GSE36640Down-0.6313301151
GSE54402Down-0.9578768352
GSE9593Up0.0415214466
GSE43922Down-0.8391075705
GSE24585Up0.5589473573
GSE37065Down-0.0132168083
GSE28863_A1Down-0.5405562964
GSE28863_A2Up0.5578799491
GSE28863_A3Down-0.4359393023
GSE28863_A4Down-0.0539425046
GSE48662Down-0.3271576698

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

{4-[2-BENZYL-3-METHOXY-2-(METHOXYCARBONYL)-3-OXOPROPYL]PHENYL}SULFAMIC ACIDDB06989 -
(4-{4-[(TERT-BUTOXYCARBONYL)AMINO]-2,2-BIS(ETHOXYCARBONYL)BUTYL}PHENYL)SULFAMIC ACIDDB07068 -
{4-[2,2-BIS(5-METHYL-1,2,4-OXADIAZOL-3-YL)-3-PHENYLPROPYL]PHENYL}SULFAMIC ACIDDB07127 -
(4-ETHYLPHENYL)SULFAMIC ACIDDB08678 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022308MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.