HCSGD entry for PTPN14
1. General information
| Official gene symbol | PTPN14 |
|---|---|
| Entrez ID | 5784 |
| Gene full name | protein tyrosine phosphatase, non-receptor type 14 |
| Other gene symbols | PEZ PTP36 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001946 | Lymphangiogenesis | IMP | biological_process |
| GO:0003712 | Transcription cofactor activity | IMP | molecular_function |
| GO:0004725 | Protein tyrosine phosphatase activity | IEA IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006470 | Protein dephosphorylation | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IMP | biological_process |
| GO:0030971 | Receptor tyrosine kinase binding | IPI | molecular_function |
| GO:0035335 | Peptidyl-tyrosine dephosphorylation | IMP TAS | biological_process |
| GO:0046825 | Regulation of protein export from nucleus | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1204953915 | 0.2536448425 | 0.7097330499 | 0.9663454282 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4367394672 |
| GSE13712_SHEAR | Up | 0.3486413102 |
| GSE13712_STATIC | Up | 0.4478898341 |
| GSE19018 | Up | 0.0086272585 |
| GSE19899_A1 | Down | -0.2991911375 |
| GSE19899_A2 | Up | 0.0617139387 |
| PubMed_21979375_A1 | Down | -0.5474418701 |
| PubMed_21979375_A2 | Up | 0.1731502561 |
| GSE35957 | Up | 0.1175367635 |
| GSE36640 | Down | -0.0132762767 |
| GSE54402 | Down | -0.3439562577 |
| GSE9593 | Up | 0.4326103674 |
| GSE43922 | Down | -0.1740512127 |
| GSE24585 | Down | -0.0306725723 |
| GSE37065 | Down | -0.2147845591 |
| GSE28863_A1 | Up | 0.5565797255 |
| GSE28863_A2 | Up | 0.7376169775 |
| GSE28863_A3 | Up | 0.0294871656 |
| GSE28863_A4 | Down | -0.1660846305 |
| GSE48662 | Up | 0.7898189711 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018677 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030954 | Microarray | Functional MTI (Weak) | 20048743 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042932 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
