HCSGD entry for PTPN12
1. General information
| Official gene symbol | PTPN12 |
|---|---|
| Entrez ID | 5782 |
| Gene full name | protein tyrosine phosphatase, non-receptor type 12 |
| Other gene symbols | PTP-PEST PTPG1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002102 | Podosome | IEA | cellular_component |
| GO:0004725 | Protein tyrosine phosphatase activity | IEA | molecular_function |
| GO:0004726 | Non-membrane spanning protein tyrosine phosphatase activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006470 | Protein dephosphorylation | TAS | biological_process |
| GO:0017124 | SH3 domain binding | IPI | molecular_function |
| GO:0030054 | Cell junction | IEA | cellular_component |
| GO:0035335 | Peptidyl-tyrosine dephosphorylation | TAS | biological_process |
| GO:0042995 | Cell projection | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0033237187 | 0.9693573762 | 0.1556994662 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2607318472 |
| GSE13712_SHEAR | Up | 0.0536795978 |
| GSE13712_STATIC | Down | -0.0076240609 |
| GSE19018 | Down | -0.0575117717 |
| GSE19899_A1 | Up | 0.6118992800 |
| GSE19899_A2 | Up | 1.1745905868 |
| PubMed_21979375_A1 | Up | 1.8091249347 |
| PubMed_21979375_A2 | Up | 1.1566658772 |
| GSE35957 | Up | 0.4090869680 |
| GSE36640 | Up | 0.0251318276 |
| GSE54402 | Up | 1.4639702623 |
| GSE9593 | Up | 0.5171299594 |
| GSE43922 | Up | 1.2035310697 |
| GSE24585 | Up | 0.3871853165 |
| GSE37065 | Up | 0.2406021906 |
| GSE28863_A1 | Up | 0.1467768216 |
| GSE28863_A2 | Up | 0.4436677227 |
| GSE28863_A3 | Down | -0.1646976873 |
| GSE28863_A4 | Down | -0.5417846090 |
| GSE48662 | Down | -0.2218405583 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-200b-3p | MIMAT0000318 | MIRT000198 | Northern blot//qRT-PCR//Western blot | Functional MTI | 16762633 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002567 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002567 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-194-5p | MIMAT0000460 | MIRT005893 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 20979124 |
| hsa-miR-375 | MIMAT0000728 | MIRT019770 | Microarray | Functional MTI (Weak) | 20215506 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
