HCSGD entry for TRIB3
1. General information
| Official gene symbol | TRIB3 |
|---|---|
| Entrez ID | 57761 |
| Gene full name | tribbles homolog 3 (Drosophila) |
| Other gene symbols | C20orf97 NIPK SINK SKIP3 TRB3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003714 | Transcription corepressor activity | IEA ISS | molecular_function |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004860 | Protein kinase inhibitor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA IEA ISS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006468 | Protein phosphorylation | IEA | biological_process |
| GO:0006469 | Negative regulation of protein kinase activity | IDA IEA | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | TAS | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0010827 | Regulation of glucose transport | IEA ISS | biological_process |
| GO:0016301 | Kinase activity | IDA | molecular_function |
| GO:0019901 | Protein kinase binding | IPI ISS | molecular_function |
| GO:0031625 | Ubiquitin protein ligase binding | IEA ISS | molecular_function |
| GO:0032092 | Positive regulation of protein binding | IEA ISS | biological_process |
| GO:0032869 | Cellular response to insulin stimulus | IEA ISS | biological_process |
| GO:0034976 | Response to endoplasmic reticulum stress | IDA | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0043405 | Regulation of MAP kinase activity | IDA | biological_process |
| GO:0044255 | Cellular lipid metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045599 | Negative regulation of fat cell differentiation | IEA ISS | biological_process |
| GO:0045717 | Negative regulation of fatty acid biosynthetic process | IEA ISS | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IMP | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0051443 | Positive regulation of ubiquitin-protein ligase activity | IEA ISS | biological_process |
| GO:0055106 | Ubiquitin-protein ligase regulator activity | IEA ISS | molecular_function |
| GO:0070059 | Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | IDA | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0084370579 | 0.5319412522 | 0.2370178270 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3695129883 |
| GSE13712_SHEAR | Up | 0.9026094398 |
| GSE13712_STATIC | Up | 0.1076239450 |
| GSE19018 | Up | 0.3414705777 |
| GSE19899_A1 | Up | 0.8105525762 |
| GSE19899_A2 | Up | 0.4402889787 |
| PubMed_21979375_A1 | Up | 1.0932139554 |
| PubMed_21979375_A2 | Up | 0.0930773010 |
| GSE35957 | Down | -0.1066675669 |
| GSE36640 | Down | -0.2770198711 |
| GSE54402 | Up | 0.2072345205 |
| GSE9593 | Up | 1.2473230969 |
| GSE43922 | Up | 0.9099391930 |
| GSE24585 | Down | -0.1667574082 |
| GSE37065 | Down | -0.7329352480 |
| GSE28863_A1 | Down | -0.2371007000 |
| GSE28863_A2 | Down | -0.6682254026 |
| GSE28863_A3 | Up | 0.2148625217 |
| GSE28863_A4 | Down | -0.0748386718 |
| GSE48662 | Up | 0.8721358140 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-24-3p | MIMAT0000080 | MIRT003354 | qRT-PCR//Western blot | Functional MTI | 20019669 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT003354 | Microarray | Functional MTI (Weak) | 19748357 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT019155 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023198 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024900 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026958 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030272 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-31-5p | MIMAT0000089 | MIRT049873 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
