HCSGD entry for PTPN4
1. General information
| Official gene symbol | PTPN4 |
|---|---|
| Entrez ID | 5775 |
| Gene full name | protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) |
| Other gene symbols | MEG PTPMEG PTPMEG1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004725 | Protein tyrosine phosphatase activity | IEA | molecular_function |
| GO:0004726 | Non-membrane spanning protein tyrosine phosphatase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0006470 | Protein dephosphorylation | TAS | biological_process |
| GO:0008092 | Cytoskeletal protein binding | IEA | molecular_function |
| GO:0009898 | Cytoplasmic side of plasma membrane | IDA | cellular_component |
| GO:0019898 | Extrinsic component of membrane | IEA | cellular_component |
| GO:0035335 | Peptidyl-tyrosine dephosphorylation | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6936531515 | 0.2413483910 | 0.9999902473 | 0.9458801370 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0732614167 |
| GSE13712_SHEAR | Down | -0.0935980275 |
| GSE13712_STATIC | Down | -0.0461867836 |
| GSE19018 | Down | -0.1228509634 |
| GSE19899_A1 | Down | -0.0861662520 |
| GSE19899_A2 | Down | -0.3508190062 |
| PubMed_21979375_A1 | Down | -0.6383605289 |
| PubMed_21979375_A2 | Down | -0.0224575978 |
| GSE35957 | Up | 0.2619280860 |
| GSE36640 | Up | 0.3014826977 |
| GSE54402 | Down | -0.3282678052 |
| GSE9593 | Up | 0.0567451982 |
| GSE43922 | Up | 0.0608937818 |
| GSE24585 | Up | 0.1460490491 |
| GSE37065 | Up | 0.0916814545 |
| GSE28863_A1 | Up | 0.2038507879 |
| GSE28863_A2 | Up | 0.3938485106 |
| GSE28863_A3 | Down | -0.9509468971 |
| GSE28863_A4 | Down | -0.2492599226 |
| GSE48662 | Up | 0.1178163270 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Alendronic acid | DB00630 | APRD00561 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020328 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-148a-3p | MIMAT0000243 | MIRT025984 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028116 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031282 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
