HCSGD entry for SPTBN4

1. General information

Official gene symbol	SPTBN4
Entrez ID	57731
Gene full name	spectrin, beta, non-erythrocytic 4
Other gene symbols	QV SPNB4 SPTBN3
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0002028	Regulation of sodium ion transport	ISS	biological_process
GO:0003779	Actin binding	IEA ISS TAS	molecular_function
GO:0005200	Structural constituent of cytoskeleton	IEA TAS	molecular_function
GO:0005515	Protein binding	IPI	molecular_function
GO:0005543	Phospholipid binding	IEA	molecular_function
GO:0005737	Cytoplasm	IDA ISS	cellular_component
GO:0005829	Cytosol	TAS	cellular_component
GO:0005886	Plasma membrane	ISS	cellular_component
GO:0005912	Adherens junction	ISS	cellular_component
GO:0007016	Cytoskeletal anchoring at plasma membrane	TAS	biological_process
GO:0007409	Axonogenesis	ISS	biological_process
GO:0007411	Axon guidance	TAS	biological_process
GO:0007605	Sensory perception of sound	ISS	biological_process
GO:0007628	Adult walking behavior	ISS	biological_process
GO:0008091	Spectrin	IDA IEA ISS	cellular_component
GO:0009566	Fertilization	IEA	biological_process
GO:0010459	Negative regulation of heart rate	ISS	biological_process
GO:0016020	Membrane	IDA	cellular_component
GO:0016192	Vesicle-mediated transport	TAS	biological_process
GO:0016363	Nuclear matrix	IDA ISS	cellular_component
GO:0016605	PML body	IDA ISS	cellular_component
GO:0019226	Transmission of nerve impulse	ISS	biological_process
GO:0019902	Phosphatase binding	IPI	molecular_function
GO:0021952	Central nervous system projection neuron axonogenesis	ISS	biological_process
GO:0030506	Ankyrin binding	IDA ISS	molecular_function
GO:0030507	Spectrin binding	ISS	molecular_function
GO:0033135	Regulation of peptidyl-serine phosphorylation	ISS	biological_process
GO:0033268	Node of Ranvier	ISS	cellular_component
GO:0033270	Paranode region of axon	IEA	cellular_component
GO:0040018	Positive regulation of multicellular organism growth	IEA	biological_process
GO:0043025	Neuronal cell body	ISS	cellular_component
GO:0043194	Axon initial segment	ISS	cellular_component
GO:0043203	Axon hillock	ISS	cellular_component
GO:0045162	Clustering of voltage-gated sodium channels	ISS	biological_process
GO:0051693	Actin filament capping	IEA	biological_process
GO:0061337	Cardiac conduction	ISS	biological_process
GO:0070852	Cell body fiber	ISS	cellular_component
GO:0090002	Establishment of protein localization to plasma membrane	ISS	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.5215419361	0.8477417575	0.9999902473	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.0405394847
GSE13712_SHEAR	Down	-0.1412486670
GSE13712_STATIC	Down	-0.0568816103
GSE19018	Up	0.1407275827
GSE19899_A1	Down	-0.0254828964
GSE19899_A2	Up	0.1068712705
PubMed_21979375_A1	Up	0.1008598405
PubMed_21979375_A2	Down	-0.0840180614
GSE35957	Up	0.0885198268
GSE36640	Up	0.0827275373
GSE54402	Up	0.0320460749
GSE9593	Up	0.1037917521
GSE43922	Up	0.0627856886
GSE24585	Up	0.3982981351
GSE37065	Down	-0.1213777490
GSE28863_A1	Down	-0.3142045023
GSE28863_A2	Up	0.0626367580
GSE28863_A3	Up	0.3240800582
GSE28863_A4	Up	0.0273613107
GSE48662	Up	0.1355731876

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Not regulated by drugs

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results