HCSGD entry for ALS2

1. General information

Official gene symbolALS2
Entrez ID57679
Gene full nameamyotrophic lateral sclerosis 2 (juvenile)
Other gene symbolsALS2CR6 ALSJ IAHSP PLSJ
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001662Behavioral fear responseIEAbiological_process
GO:0001726RuffleIEA ISScellular_component
GO:0001881Receptor recyclingIEAbiological_process
GO:0005085Guanyl-nucleotide exchange factor activityIDAmolecular_function
GO:0005087Ran guanyl-nucleotide exchange factor activityNASmolecular_function
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIEAcellular_component
GO:0005769Early endosomeIDAcellular_component
GO:0005813CentrosomeIDA IEAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0006979Response to oxidative stressIEAbiological_process
GO:0007032Endosome organizationIGI NASbiological_process
GO:0007528Neuromuscular junction developmentIEAbiological_process
GO:0007626Locomotory behaviorIEAbiological_process
GO:0008104Protein localizationIEAbiological_process
GO:0008219Cell deathIEAbiological_process
GO:0014069Postsynaptic densityIEAcellular_component
GO:0016050Vesicle organizationIEAbiological_process
GO:0016197Endosomal transportIEAbiological_process
GO:0017112Rab guanyl-nucleotide exchange factor activityIDAmolecular_function
GO:0017137Rab GTPase bindingIDA NASmolecular_function
GO:0030027LamellipodiumIEA ISScellular_component
GO:0030425DendriteIDAcellular_component
GO:0030426Growth coneISScellular_component
GO:0030676Rac guanyl-nucleotide exchange factor activityIDAmolecular_function
GO:0031982VesicleIDAcellular_component
GO:0032313Regulation of Rab GTPase activityIEAbiological_process
GO:0032314Regulation of Rac GTPase activityIDAbiological_process
GO:0032316Regulation of Ran GTPase activityNASbiological_process
GO:0032855Positive regulation of Rac GTPase activityIDAbiological_process
GO:0035022Positive regulation of Rac protein signal transductionICbiological_process
GO:0035249Synaptic transmission, glutamatergicIEAbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043197Dendritic spineIEAcellular_component
GO:0043234Protein complexIDAcellular_component
GO:0043539Protein serine/threonine kinase activator activityIDAmolecular_function
GO:0045860Positive regulation of protein kinase activityIDAbiological_process
GO:0048812Neuron projection morphogenesisIDAbiological_process
GO:0051036Regulation of endosome sizeIEPbiological_process
GO:0071902Positive regulation of protein serine/threonine kinase activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.15344045060.89876127430.77996389421.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1327831987
GSE13712_SHEARUp0.0995237303
GSE13712_STATICUp0.2055025192
GSE19018Down-0.0358103579
GSE19899_A1Down-0.0081835664
GSE19899_A2Down-0.0466709331
PubMed_21979375_A1Down-0.0931940853
PubMed_21979375_A2Up0.2016461073
GSE35957Down-0.0643623883
GSE36640Up0.0362306474
GSE54402Up0.0704488889
GSE9593Up0.0453605401
GSE43922Up0.0523812238
GSE24585Up0.5793884623
GSE37065Up0.0921326613
GSE28863_A1Up0.3558148980
GSE28863_A2Up0.9788943288
GSE28863_A3Down-0.1511344500
GSE28863_A4Down-0.1487671461
GSE48662Down-0.2571804283

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1229-3pMIMAT0005584MIRT036325CLASHFunctional MTI (Weak)23622248
hsa-miR-93-3pMIMAT0004509MIRT038866CLASHFunctional MTI (Weak)23622248
hsa-miR-34a-5pMIMAT0000255MIRT047362CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.