HCSGD entry for PHF12
1. General information
| Official gene symbol | PHF12 |
|---|---|
| Entrez ID | 57649 |
| Gene full name | PHD finger protein 12 |
| Other gene symbols | PF1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0001106 | RNA polymerase II transcription corepressor activity | IDA | molecular_function |
| GO:0001222 | Transcription corepressor binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0016580 | Sin3 complex | IDA | cellular_component |
| GO:0017053 | Transcriptional repressor complex | IDA | cellular_component |
| GO:0035091 | Phosphatidylinositol binding | IDA | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1184980472 | 0.8945773489 | 0.7062923687 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1943392228 |
| GSE13712_SHEAR | Up | 0.3508011799 |
| GSE13712_STATIC | Up | 0.0761333052 |
| GSE19018 | Down | -0.1540240372 |
| GSE19899_A1 | Up | 0.0810457434 |
| GSE19899_A2 | Up | 0.2769036818 |
| PubMed_21979375_A1 | Down | -0.0555220372 |
| PubMed_21979375_A2 | Up | 0.5687285202 |
| GSE35957 | Down | -0.0411144599 |
| GSE36640 | Up | 0.0497934513 |
| GSE54402 | Up | 0.1506251459 |
| GSE9593 | Down | -0.1692861156 |
| GSE43922 | Up | 0.0021344487 |
| GSE24585 | Up | 0.1208486184 |
| GSE37065 | Up | 0.2199744962 |
| GSE28863_A1 | Up | 0.4361436831 |
| GSE28863_A2 | Up | 0.5582814833 |
| GSE28863_A3 | Down | -0.1721063331 |
| GSE28863_A4 | Down | -0.0580375642 |
| GSE48662 | Down | -0.0280850397 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-221-3p | MIMAT0000278 | MIRT024170 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-320b | MIMAT0005792 | MIRT036211 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-454-3p | MIMAT0003885 | MIRT039249 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-652-3p | MIMAT0003322 | MIRT039475 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049291 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 12391155 | Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split |
| 12391155 | Pf1 is a plant homeodomain zinc finger protein that interacts with both mSin3A and TLE, suggesting that it coordinates their function |
| 12391155 | While the MORFs may have common functions, MRG15, but not MRGX or MORF4, interacted with Pf1 |
| 12391155 | Consistent with this hypothesis, Pf1 reduced transcriptional repression by Gal4-MRG15 but it had no effect on repression by MRGX and MORF4 |
| 12391155 | Pf1 has independent binding sites for MRG15 and mSin3A |
| 12391155 | In addition, Pf1 and MRG15 bind different domains on mSin3A |
| 12391155 | Together, these data suggest that the unique functions of MRG15 are elicited through the action of an MRG15/Pf1/mSin3A complex |
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