HCSGD entry for USP28
1. General information
| Official gene symbol | USP28 |
|---|---|
| Entrez ID | 57646 |
| Gene full name | ubiquitin specific peptidase 28 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000077 | DNA damage checkpoint | IMP | biological_process |
| GO:0004221 | Ubiquitin thiolesterase activity | IEA IMP | molecular_function |
| GO:0004843 | Ubiquitin-specific protease activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA | biological_process |
| GO:0008234 | Cysteine-type peptidase activity | IEA | molecular_function |
| GO:0008283 | Cell proliferation | IMP | biological_process |
| GO:0010212 | Response to ionizing radiation | IDA | biological_process |
| GO:0016579 | Protein deubiquitination | IDA | biological_process |
| GO:0034644 | Cellular response to UV | IDA | biological_process |
| GO:0042771 | Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | IDA | biological_process |
| GO:0043234 | Protein complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9429612743 | 0.0090157783 | 0.9999902473 | 0.1878893903 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4031153176 |
| GSE13712_SHEAR | Down | -0.1229460641 |
| GSE13712_STATIC | Down | -0.1637894356 |
| GSE19018 | Up | 0.1438664297 |
| GSE19899_A1 | Down | -0.3900237676 |
| GSE19899_A2 | Down | -1.4608140847 |
| PubMed_21979375_A1 | Down | -0.6182220367 |
| PubMed_21979375_A2 | Down | -0.8122031756 |
| GSE35957 | Down | -0.4140774318 |
| GSE36640 | Down | -1.9149516347 |
| GSE54402 | Down | -0.0942549070 |
| GSE9593 | Down | -0.5319351447 |
| GSE43922 | Down | -0.7710451834 |
| GSE24585 | Down | -0.0137678818 |
| GSE37065 | Up | 0.3940610557 |
| GSE28863_A1 | Up | 0.5112303335 |
| GSE28863_A2 | Up | 0.5330585454 |
| GSE28863_A3 | Down | -0.7891704231 |
| GSE28863_A4 | Up | 0.0564607519 |
| GSE48662 | Down | -0.0237380290 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-122-5p | MIMAT0000421 | MIRT023273 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025164 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-1301-3p | MIMAT0005797 | MIRT036013 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039972 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046845 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
