HCSGD entry for MKL1

1. General information

Official gene symbolMKL1
Entrez ID57591
Gene full namemegakaryoblastic leukemia (translocation) 1
Other gene symbolsBSAC MAL MRTF-A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000976Transcription regulatory region sequence-specific DNA bindingIEAmolecular_function
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0003713Transcription coactivator activityISSmolecular_function
GO:0003779Actin bindingIEAmolecular_function
GO:0003785Actin monomer bindingISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0043522Leucine zipper domain bindingIPImolecular_function
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0051145Smooth muscle cell differentiationIMPbiological_process
GO:2001234Negative regulation of apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.22773456940.95822262830.90964280081.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0178232766
GSE13712_SHEARUp0.0752456449
GSE13712_STATICUp0.3490932481
GSE19018Up0.0948146027
GSE19899_A1Up0.0434307649
GSE19899_A2Up0.3111595879
PubMed_21979375_A1Up0.5316599412
PubMed_21979375_A2Up0.2456475956
GSE35957Up0.0555865731
GSE36640Down-0.0228075388
GSE54402Up0.0297622724
GSE9593Down-0.1479271160
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Up0.3013829462
GSE28863_A2Down-0.0130812114
GSE28863_A3Up0.1760327430
GSE28863_A4Down-0.0883940715
GSE48662Up0.2142377488

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

LATRUNCULIN BDB08080 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-183-5pMIMAT0000261MIRT047070CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.