HCSGD entry for TWF1
1. General information
| Official gene symbol | TWF1 |
|---|---|
| Entrez ID | 5756 |
| Gene full name | twinfilin actin-binding protein 1 |
| Other gene symbols | A6 PTK9 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003779 | Actin binding | IEA | molecular_function |
| GO:0003785 | Actin monomer binding | ISS | molecular_function |
| GO:0004713 | Protein tyrosine kinase activity | IDA | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0005546 | Phosphatidylinositol-4,5-bisphosphate binding | ISS | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005911 | Cell-cell junction | ISS | cellular_component |
| GO:0015629 | Actin cytoskeleton | ISS | cellular_component |
| GO:0030016 | Myofibril | ISS | cellular_component |
| GO:0030175 | Filopodium | ISS | cellular_component |
| GO:0030837 | Negative regulation of actin filament polymerization | IEA ISS | biological_process |
| GO:0032587 | Ruffle membrane | ISS | cellular_component |
| GO:0042989 | Sequestering of actin monomers | ISS | biological_process |
| GO:0043538 | Regulation of actin phosphorylation | IDA | biological_process |
| GO:0048471 | Perinuclear region of cytoplasm | ISS | cellular_component |
| GO:0051016 | Barbed-end actin filament capping | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7688922267 | 0.2702923521 | 0.9999902473 | 0.9941818055 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0838614185 |
| GSE13712_SHEAR | Up | 0.0069863382 |
| GSE13712_STATIC | Up | 0.0436578743 |
| GSE19018 | Down | -0.0460345215 |
| GSE19899_A1 | Down | -0.0293048521 |
| GSE19899_A2 | Down | -0.3417632178 |
| PubMed_21979375_A1 | Up | 0.1551661354 |
| PubMed_21979375_A2 | Down | -0.8022202664 |
| GSE35957 | Up | 0.2538741947 |
| GSE36640 | Down | -0.1169969428 |
| GSE54402 | Up | 0.0174921733 |
| GSE9593 | Up | 0.1785272800 |
| GSE43922 | Down | -0.0030611115 |
| GSE24585 | Up | 0.0099532462 |
| GSE37065 | Down | -0.0453019518 |
| GSE28863_A1 | Down | -0.0125998466 |
| GSE28863_A2 | Up | 0.9207981360 |
| GSE28863_A3 | Down | -0.1793684656 |
| GSE28863_A4 | Down | -0.0006977701 |
| GSE48662 | Down | -0.6499781135 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT005089 | Microarray//Microarray;Other | Functional MTI (Weak) | 15685193 |
| hsa-miR-1 | MIMAT0000416 | MIRT005089 | pSILAC | Functional MTI (Weak) | 18668040 |
| hsa-miR-1 | MIMAT0000416 | MIRT005089 | Luciferase reporter assay//Microarray//Northern blot//qRT-PCR//Western blot | Functional MTI | 20571053 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT005164 | pSILAC | Functional MTI (Weak) | 18668040 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT005246 | pSILAC | Functional MTI (Weak) | 18668040 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT005246 | Proteomics;Other | Functional MTI (Weak) | 20584899 |
| hsa-miR-126-3p | MIMAT0000445 | MIRT005538 | Luciferase reporter assay//Microarray//Northern blot//qRT-PCR//Western blot | Non-Functional MTI | 20571053 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT007203 | Luciferase reporter assay | Functional MTI | 23224145 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041291 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | NA | hsa-miR-1 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
