HCSGD entry for PDP2
1. General information
| Official gene symbol | PDP2 |
|---|---|
| Entrez ID | 57546 |
| Gene full name | pyruvate dehyrogenase phosphatase catalytic subunit 2 |
| Other gene symbols | PPM2C2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004724 | Magnesium-dependent protein serine/threonine phosphatase activity | IEA | molecular_function |
| GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005759 | Mitochondrial matrix | TAS | cellular_component |
| GO:0006090 | Pyruvate metabolic process | TAS | biological_process |
| GO:0010510 | Regulation of acetyl-CoA biosynthetic process from pyruvate | TAS | biological_process |
| GO:0035970 | Peptidyl-threonine dephosphorylation | IEA | biological_process |
| GO:0044237 | Cellular metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0099280726 | 0.4369926599 | 0.2542315175 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.5009237382 |
| GSE13712_SHEAR | Down | -0.0664087230 |
| GSE13712_STATIC | Up | 0.1995747016 |
| GSE19018 | Up | 0.1005986872 |
| GSE19899_A1 | Up | 0.6078178036 |
| GSE19899_A2 | Up | 1.0448134213 |
| PubMed_21979375_A1 | Up | 0.9383233563 |
| PubMed_21979375_A2 | Up | 2.0053504548 |
| GSE35957 | Down | -0.3524241239 |
| GSE36640 | Up | 0.2309946584 |
| GSE54402 | Up | 0.7340113042 |
| GSE9593 | Up | 0.4051324344 |
| GSE43922 | Up | 0.6669442125 |
| GSE24585 | Down | -0.2315406764 |
| GSE37065 | Down | -0.2240742016 |
| GSE28863_A1 | Down | -0.3528461493 |
| GSE28863_A2 | Down | -0.2101226349 |
| GSE28863_A3 | Down | -1.1361340415 |
| GSE28863_A4 | Down | -0.0480901908 |
| GSE48662 | Up | 0.4116689896 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7e-5p | MIMAT0000066 | MIRT051639 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052354 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23685455 | BRAF(V600E)-induced senescence was accompanied by simultaneous suppression of the PDH-inhibitory enzyme pyruvate dehydrogenase kinase 1 (PDK1) and induction of the PDH-activating enzyme pyruvate dehydrogenase phosphatase 2 (PDP2) |
| 23685455 | Further supporting a crucial role of PDH in OIS, enforced normalization of either PDK1 or PDP2 expression levels inhibited PDH and abrogated OIS, thereby licensing BRAF(V600E)-driven melanoma development |
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