HCSGD entry for CNOT6
1. General information
| Official gene symbol | CNOT6 |
|---|---|
| Entrez ID | 57472 |
| Gene full name | CCR4-NOT transcription complex, subunit 6 |
| Other gene symbols | CCR4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000288 | Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | TAS | biological_process |
| GO:0000289 | Nuclear-transcribed mRNA poly(A) tail shortening | TAS | biological_process |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0004532 | Exoribonuclease activity | IDA | molecular_function |
| GO:0004535 | Poly(A)-specific ribonuclease activity | IDA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006417 | Regulation of translation | IEA | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IMP | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010606 | Positive regulation of cytoplasmic mRNA processing body assembly | IMP | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0030014 | CCR4-NOT complex | IDA | cellular_component |
| GO:0035195 | Gene silencing by miRNA | TAS | biological_process |
| GO:0043928 | Exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | IDA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0070966 | Nuclear-transcribed mRNA catabolic process, no-go decay | IMP | biological_process |
| GO:0090305 | Nucleic acid phosphodiester bond hydrolysis | IDA TAS | biological_process |
| GO:0090501 | RNA phosphodiester bond hydrolysis | IDA TAS | biological_process |
| GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic | IDA TAS | biological_process |
| GO:2000327 | Positive regulation of ligand-dependent nuclear receptor transcription coactivator activity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5359937806 | 0.1688838000 | 0.9999902473 | 0.7949196173 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1972911364 |
| GSE13712_SHEAR | Up | 0.0401986283 |
| GSE13712_STATIC | Up | 0.0942476759 |
| GSE19018 | Down | -0.3841525036 |
| GSE19899_A1 | Down | -0.0321420260 |
| GSE19899_A2 | Down | -0.4359321342 |
| PubMed_21979375_A1 | Up | 0.2457346714 |
| PubMed_21979375_A2 | Up | 0.2983486520 |
| GSE35957 | Down | -0.5447324198 |
| GSE36640 | Down | -0.8923669897 |
| GSE54402 | Up | 0.1632041207 |
| GSE9593 | Down | -0.6961219584 |
| GSE43922 | Up | 0.0402102898 |
| GSE24585 | Up | 0.2217037316 |
| GSE37065 | Up | 0.2674333323 |
| GSE28863_A1 | Up | 0.5175105089 |
| GSE28863_A2 | Up | 0.6457168561 |
| GSE28863_A3 | Down | -0.1969762926 |
| GSE28863_A4 | Down | -0.2611104262 |
| GSE48662 | Down | -0.0804993677 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT003851 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-373-3p | MIMAT0000726 | MIRT004074 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016605 | Microarray | Functional MTI (Weak) | 20304954 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020329 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-9-5p | MIMAT0000441 | MIRT021485 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-96-5p | MIMAT0000095 | MIRT027912 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031275 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-15a-3p | MIMAT0004488 | MIRT038987 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-769-5p | MIMAT0003886 | MIRT039160 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT044283 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-183-5p | MIMAT0000261 | MIRT047042 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | NA | hsa-miR-1 | 15685193 | |||
| hsa-miR-373-3p | MIMAT0000726 | NA | hsa-miR-373 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26792405 | Dual-luciferase reporter assays demonstrated that CNOT6 is the target gene of miR-29c-3p |
| 26792405 | Knockdown of CNOT6 confirmed its inhibitory effects on the senescence of MSCs |
| 26792405 | In conclusion, our results demonstrate that miR-29c-3p promotes the senescence of MSCs by targeting CNOT6 through p53-p21 and p16-pRB pathways and highlight the contribution of post-transcriptional regulation to stem cell senescence |
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