HCSGD entry for PTK2
1. General information
| Official gene symbol | PTK2 |
|---|---|
| Entrez ID | 5747 |
| Gene full name | protein tyrosine kinase 2 |
| Other gene symbols | FADK FAK FAK1 FRNK PPP1R71 p125FAK pp125FAK |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000226 | Microtubule cytoskeleton organization | IEA | biological_process |
| GO:0001525 | Angiogenesis | IEA TAS | biological_process |
| GO:0001570 | Vasculogenesis | IEA | biological_process |
| GO:0001764 | Neuron migration | IEA | biological_process |
| GO:0001890 | Placenta development | TAS | biological_process |
| GO:0001934 | Positive regulation of protein phosphorylation | IMP | biological_process |
| GO:0003007 | Heart morphogenesis | TAS | biological_process |
| GO:0003779 | Actin binding | IDA | molecular_function |
| GO:0004672 | Protein kinase activity | IEA TAS | molecular_function |
| GO:0004713 | Protein tyrosine kinase activity | IEA | molecular_function |
| GO:0004715 | Non-membrane spanning protein tyrosine kinase activity | IDA | molecular_function |
| GO:0004871 | Signal transducer activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005815 | Microtubule organizing center | IEA | cellular_component |
| GO:0005829 | Cytosol | IDA TAS | cellular_component |
| GO:0005856 | Cytoskeleton | IEA TAS | cellular_component |
| GO:0005925 | Focal adhesion | IDA IEA | cellular_component |
| GO:0005938 | Cell cortex | IEA | cellular_component |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0006921 | Cellular component disassembly involved in execution phase of apoptosis | TAS | biological_process |
| GO:0007172 | Signal complex assembly | IEA | biological_process |
| GO:0007229 | Integrin-mediated signaling pathway | IMP TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA ISS | biological_process |
| GO:0008360 | Regulation of cell shape | IMP | biological_process |
| GO:0008432 | JUN kinase binding | IDA | molecular_function |
| GO:0009790 | Embryo development | TAS | biological_process |
| GO:0010594 | Regulation of endothelial cell migration | TAS | biological_process |
| GO:0014068 | Positive regulation of phosphatidylinositol 3-kinase signaling | IMP | biological_process |
| GO:0016324 | Apical plasma membrane | IEA | cellular_component |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | IDA | biological_process |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0021955 | Central nervous system neuron axonogenesis | IEA | biological_process |
| GO:0022408 | Negative regulation of cell-cell adhesion | IDA | biological_process |
| GO:0030010 | Establishment of cell polarity | TAS | biological_process |
| GO:0030027 | Lamellipodium | IEA | cellular_component |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | IEA | biological_process |
| GO:0030335 | Positive regulation of cell migration | IDA | biological_process |
| GO:0032319 | Regulation of Rho GTPase activity | TAS | biological_process |
| GO:0033628 | Regulation of cell adhesion mediated by integrin | IDA | biological_process |
| GO:0038007 | Netrin-activated signaling pathway | TAS | biological_process |
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | TAS | biological_process |
| GO:0040023 | Establishment of nucleus localization | IEA | biological_process |
| GO:0042127 | Regulation of cell proliferation | IMP | biological_process |
| GO:0042169 | SH2 domain binding | IPI | molecular_function |
| GO:0043066 | Negative regulation of apoptotic process | IMP | biological_process |
| GO:0043542 | Endothelial cell migration | IEA | biological_process |
| GO:0043552 | Positive regulation of phosphatidylinositol 3-kinase activity | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045667 | Regulation of osteoblast differentiation | IMP | biological_process |
| GO:0045860 | Positive regulation of protein kinase activity | IMP | biological_process |
| GO:0046621 | Negative regulation of organ growth | IEA | biological_process |
| GO:0046777 | Protein autophosphorylation | IDA IEA | biological_process |
| GO:0048013 | Ephrin receptor signaling pathway | IDA | biological_process |
| GO:0048870 | Cell motility | TAS | biological_process |
| GO:0050771 | Negative regulation of axonogenesis | IEA | biological_process |
| GO:0051493 | Regulation of cytoskeleton organization | TAS | biological_process |
| GO:0051893 | Regulation of focal adhesion assembly | TAS | biological_process |
| GO:0051897 | Positive regulation of protein kinase B signaling | IMP | biological_process |
| GO:0051964 | Negative regulation of synapse assembly | IEA | biological_process |
| GO:0060396 | Growth hormone receptor signaling pathway | IDA | biological_process |
| GO:2000060 | Positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process | IEA ISS | biological_process |
| GO:2000811 | Negative regulation of anoikis | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1158472019 | 0.9350308879 | 0.6987200275 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0973232332 |
| GSE13712_SHEAR | Up | 0.3449308586 |
| GSE13712_STATIC | Up | 0.1530823981 |
| GSE19018 | Up | 0.2314578131 |
| GSE19899_A1 | Up | 0.0825430184 |
| GSE19899_A2 | Up | 0.5380605648 |
| PubMed_21979375_A1 | Up | 0.4983173407 |
| PubMed_21979375_A2 | Up | 0.3763173599 |
| GSE35957 | Down | -0.1216073572 |
| GSE36640 | Up | 0.1684755092 |
| GSE54402 | Up | 0.4247541954 |
| GSE9593 | Up | 0.3708760896 |
| GSE43922 | Down | -0.0186684245 |
| GSE24585 | Up | 0.0460009030 |
| GSE37065 | Up | 0.1532356685 |
| GSE28863_A1 | Up | 0.2047364301 |
| GSE28863_A2 | Up | 0.0136662856 |
| GSE28863_A3 | Down | -0.4396404034 |
| GSE28863_A4 | Up | 0.0680132206 |
| GSE48662 | Down | -0.3676168964 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| 7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE | DB07248 | - |
| 2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE | DB07460 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-138-5p | MIMAT0000430 | MIRT006388 | Luciferase reporter assay//Western blot | Functional MTI | 21444814 |
| hsa-miR-193a-3p | MIMAT0000459 | MIRT004001 | Luciferase reporter assay//qRT-PCR//Western blot | Non-Functional MTI | 18381414 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT006900 | Immunoblot//Immunohistochemistry//Luciferase reporter assay//qRT-PCR | Functional MTI | 22876288 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030918 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051491 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051867 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-193a-3p | MIMAT0000459 | NA | hsa-miR-193a-3p | {Western blot} | {overexpression by miRNA precursor transfection} | 18381414 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26873092 | We found that circ-Foxo3 was mainly distributed in the cytoplasm, where it interacted with the anti-senescent protein ID-1 and the transcription factor E2F1, as well as the anti-stress proteins FAK and HIF1alpha |
| 26873092 | CONCLUSION: We conclude that ID-1, E2F1, FAK, and HIF1alpha interact with circ-Foxo3 and are retained in the cytoplasm and could no longer exert their anti-senescent and anti-stress roles, resulting in increased cellular senescence |
| 25693733 | Fucoidan also promoted the expression of cell cycle-associated proteins (cyclin E, Cdk2, cyclin D1, and Cdk4) in senescent ECFCs, significantly reversed cellular senescence, and increased the proliferation of ECFCs via the FAK, Akt, and ERK signaling pathways |
| 25472717 | This upregulates the downstream proteins CEBPB, FAK, N-cadherin, vimentin, Oct4 and Sca-1 (also known as stem cell antigen-1), and downregulates E-cadherin |
| 24041229 | The interaction between FAK, MYCN, p53 and Mdm2 in neuroblastoma |
| 24041229 | This review focuses on the individual protein tyrosine kinase, focal adhesion kinase (FAK) and its interaction with the transcription factors, MYCN, p53, and Mdm2, and how their interactions modulate the growth and malignancy of neuroblastomas |
| 16523241 | We showed that focal adhesion kinase (FAK) expression and its phosphorylation at Tyr397, autophosphorylation site for focal adhesion formation, and Tyr577, Src-dependent phosphorylation site, were both increased in senescent cells |
| 16523241 | Moreover, FAK was inactivated proteolytically by apoptotic stimuli in young cells, but not in senescent cells |
| 16523241 | Interestingly dephosphorylation at Tyr577 of FAK by PP2 treatment, Src-family kinase inhibitor, induced the apoptosis by staurosporine in senescent cells but dephosphorylation at Tyr397 by downregulation of caveolin-1 was not affected |
| 16523241 | These data suggest that FAK might differently regulate apoptosis and focal adhesion formation through site-specific tyrosine phosphorylation in senescent cells |
| 15263006 | We observed that the expression integrin beta(1) and focal adhesion kinase (FAK) were increased and that the phosphorylations of FAK and paxillin, hallmarks of focal adhesion formation, were also increased in senescent human diploid fibroblast cells |
| 15263006 | Interestingly, caveolin-1 knock-out senescent cells, achieved by using small interfering RNA and antisense oligonucleotide, showed disrupted focal adhesion formation and actin stress fibers via the inactivation of FAK, which resulted in morphological adjustment to the young cell-like small spindle shape |
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