HCSGD entry for PTH1R

1. General information

Official gene symbolPTH1R
Entrez ID5745
Gene full nameparathyroid hormone 1 receptor
Other gene symbolsPFE PTHR PTHR1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001501Skeletal system developmentTASbiological_process
GO:0002062Chondrocyte differentiationIEAbiological_process
GO:0002076Osteoblast developmentIEAbiological_process
GO:0004991Parathyroid hormone receptor activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005886Plasma membraneIEA TAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerTASbiological_process
GO:0007188Adenylate cyclase-modulating G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007189Adenylate cyclase-activating G-protein coupled receptor signaling pathwayIEA ISSbiological_process
GO:0007200Phospholipase C-activating G-protein coupled receptor signaling pathwayIC IEAbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008285Negative regulation of cell proliferationIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016323Basolateral plasma membraneIEA ISScellular_component
GO:0016324Apical plasma membraneIEA ISScellular_component
GO:0017046Peptide hormone bindingIDAmolecular_function
GO:0030282Bone mineralizationIEAbiological_process
GO:0031526Brush border membraneIEAcellular_component
GO:0043235Receptor complexIEA ISScellular_component
GO:0043621Protein self-associationIDAmolecular_function
GO:0045453Bone resorptionIEAbiological_process
GO:0048469Cell maturationIEAbiological_process
GO:0060732Positive regulation of inositol phosphate biosynthetic processIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.29783163630.87332544740.99689641501.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0074899260
GSE13712_SHEARDown-0.2458454779
GSE13712_STATICUp0.0014557893
GSE19018Up0.1405381886
GSE19899_A1Down-0.0291954322
GSE19899_A2Up0.3030133792
PubMed_21979375_A1Down-0.5091578694
PubMed_21979375_A2Down-0.0116882498
GSE35957Up0.5535510098
GSE36640Up0.4088337475
GSE54402Down-0.1314865985
GSE9593Down-0.0835793614
GSE43922Up0.0817657172
GSE24585Down-0.0462256577
GSE37065Down-0.0025705550
GSE28863_A1Up0.1279595973
GSE28863_A2Up0.1671836213
GSE28863_A3Up0.2925493816
GSE28863_A4Up0.0311413123
GSE48662Up0.2906855800

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Parathyroid hormoneDB05829 -
TeriparatideDB06285 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.