HCSGD entry for PLEKHG5

1. General information

Official gene symbolPLEKHG5
Entrez ID57449
Gene full namepleckstrin homology domain containing, family G (with RhoGef domain) member 5
Other gene symbolsDSMA4 GEF720 Syx Tech
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004871Signal transducer activityIMPmolecular_function
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005737CytoplasmISScellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0005911Cell-cell junctionISScellular_component
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0030027LamellipodiumISScellular_component
GO:0030139Endocytic vesicleISScellular_component
GO:0035767Endothelial cell chemotaxisISSbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIMPbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.15521590370.78421297060.78310097761.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2405287120
GSE13712_SHEARDown-0.1279497657
GSE13712_STATICDown-0.0446252560
GSE19018Up0.0802115799
GSE19899_A1Down-0.0150371862
GSE19899_A2Up0.5437146318
PubMed_21979375_A1Up0.3013424385
PubMed_21979375_A2Up0.4063571619
GSE35957Up0.1967619458
GSE36640Up0.0814616091
GSE54402Up0.2368345413
GSE9593Up0.0582497851
GSE43922Up0.2220240321
GSE24585Down-0.1006512207
GSE37065Up0.0636848096
GSE28863_A1Down-0.3116911958
GSE28863_A2Down-0.1069076277
GSE28863_A3Up0.2639084705
GSE28863_A4Down-0.0978205710
GSE48662Down-0.2037658733

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.