HCSGD entry for PTHLH
1. General information
| Official gene symbol | PTHLH |
|---|---|
| Entrez ID | 5744 |
| Gene full name | parathyroid hormone-like hormone |
| Other gene symbols | BDE2 HHM PLP PTHR PTHRP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001501 | Skeletal system development | IDA | biological_process |
| GO:0001958 | Endochondral ossification | IEA | biological_process |
| GO:0002076 | Osteoblast development | IEA | biological_process |
| GO:0005179 | Hormone activity | IEA | molecular_function |
| GO:0005576 | Extracellular region | IEA TAS | cellular_component |
| GO:0005615 | Extracellular space | TAS | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0007189 | Adenylate cyclase-activating G-protein coupled receptor signaling pathway | IDA | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0007492 | Endoderm development | IEA | biological_process |
| GO:0007565 | Female pregnancy | TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IEA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0008544 | Epidermis development | TAS | biological_process |
| GO:0010468 | Regulation of gene expression | IDA | biological_process |
| GO:0016485 | Protein processing | IEA | biological_process |
| GO:0030819 | Positive regulation of cAMP biosynthetic process | IDA | biological_process |
| GO:0030855 | Epithelial cell differentiation | IEA | biological_process |
| GO:0032330 | Regulation of chondrocyte differentiation | IEA | biological_process |
| GO:0032331 | Negative regulation of chondrocyte differentiation | IDA IEA | biological_process |
| GO:0043129 | Surfactant homeostasis | IEA | biological_process |
| GO:0043433 | Negative regulation of sequence-specific DNA binding transcription factor activity | IEA | biological_process |
| GO:0046058 | CAMP metabolic process | TAS | biological_process |
| GO:0048286 | Lung alveolus development | IEA | biological_process |
| GO:0051428 | Peptide hormone receptor binding | IDA | molecular_function |
| GO:0060649 | Mammary gland bud elongation | IEA | biological_process |
| GO:0060659 | Nipple sheath formation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0328472968 | 0.1261908552 | 0.4178906718 | 0.6838520692 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 1.9532145401 |
| GSE13712_SHEAR | Down | -0.2858469537 |
| GSE13712_STATIC | Down | -0.0846100487 |
| GSE19018 | Down | -3.1473449999 |
| GSE19899_A1 | Up | 0.3245284922 |
| GSE19899_A2 | Down | -0.5746045861 |
| PubMed_21979375_A1 | Up | 2.0943439490 |
| PubMed_21979375_A2 | Up | 0.5612545906 |
| GSE35957 | Down | -0.3005218881 |
| GSE36640 | Up | 0.0095300680 |
| GSE54402 | Down | -0.2898097191 |
| GSE9593 | Up | 0.0985141978 |
| GSE43922 | Up | 0.2501056717 |
| GSE24585 | Up | 0.1435926861 |
| GSE37065 | Up | 1.0595151442 |
| GSE28863_A1 | Up | 0.0498283582 |
| GSE28863_A2 | Up | 0.0938609028 |
| GSE28863_A3 | Up | 0.0303246308 |
| GSE28863_A4 | Down | -0.1750290856 |
| GSE48662 | Down | -0.0735808609 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-33a-5p | MIMAT0000091 | MIRT035547 | Luciferase reporter assay | Functional MTI | 23453925 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 15610763 | Genes specifically up-regulated by transdifferentiation but not by cellular senescence of PrSCs were metalloproteinase 1 tissue inhibitor (Timp1), transgelin (Tagln), gamma 2 actin (Actg2), plasminogen activator inhibitor 1 (Serpinel), insulin-like growth factor binding protein 3 (Igfbp3), parathyroid hormone-like hormone (Pthlp), Tgfb-1, four and a half LIM domains 2 (Fhl-2), hydrogen peroxide-inducible clone 5 (Hic5) and cartilage oligomeric matrix protein (Comp) |
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